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http://hdl.handle.net/20.500.14454/1634

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Examinando Artículos por Autor "Adams, Hieab"

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    A genome-wide association meta-analysis of all-cause and vascular dementia
    (John Wiley and Sons Inc, 2024-09) Fongang, Bernard; Sargurupremraj, Muralidharan; Jian, Xueqiu; Mishra, Aniket; Damotte, Vincent; Rojas, Itziar de; Skrobot, Olivia; Bis, Joshua C.; Fan, Kang-Hsien; Jacobsen, Erin; Li, Gloria Hoi-Yee; Yang, Jingyun; Alessandra, Bizzarro; Alessandra, Lauria; Hilal, Saima; Chong, Joyce Ruifen; Chai, Yuek Ling; Knol, M.J.; Pina Concas, Maria; Giorgia, Girotto; Riaz, Moeen; Yu, Chenglong; Guojonsson, Alexander; Lacaze, Paul; Naj, Adam C.; Gireud-Goss, Monica; Wadop, Yannick N.; Soumare, Aicha; Bouteloup, Vincent; Gudnason, Vilmundur; Battista, Petronilla; Santin, Aurora; Spedicati, Beatrice; Sardone, Rodolfo; Launer, Lenore; Bressler, Jan; Gottesman, Rebecca F.; Le Grand, Quentin; Caro, Ilana; Roshchupkin, Gennady V.; Leonard, Hampton L.; Yang, Chaojie; Bartz, Traci M.; Bordes, Constance; Ridker, Paul M.; Geerlings, Mirjam I.; Gasca, Natalie C.; Manichaikul, Ani; Nalls, Mike A.; Rich, Stephen S.; Schmidt, Carsten O.; Trompet, Stella; Setten, Jessica van; Vugt, Marion van; Grabe, Hans J.; Jukema, J. Wouter; Rissanen, Ina L.; Wassertheil-Smoller, Sylvia; Ikram, M. Arfan; Simonsick, Eleanor M.; Longstreth, W.T. ; Chasman, Daniel I.; Rotter, Jerome I.; Sattar, Naveed; Stott, David J.; Shiroma, Eric J.; Sigurdsson, Sigurdur; Ghanbari, Mohsen; Schminke, Ulf; Boerwinkle, Eric; Aparicio, Hugo J.; Beiser, Alexa S.; Romero, José R.; Lioutas, Vasileios; Wang, Ruiqi; Sarnowski, Chloe; Teumer, Alexander; Völker, Uwe; Mosley, Thomas H.; Marquié, Marta; García González, Pablo; Olivé, Clàudia; Puerta, Raquel; Cano, Amanda; Sotolongo Grau, Óscar; Valero, Sergi; Pytel, Vanesa Verónica; Rosende-Roca, Maitée; Alegret, Montserrat; Tàrraga, Lluís; Boada, Mercè; Carracedo, Ángel; Franco Macías, Emilio; Piñol Ripoll, Gerard; García Ribas, Guillermo; Pérez Tur, Jordi; Royo, Jose Luís; García Alberca, Jose María; Real, Luis Miguel; Sáez, María Eugenia; Bullido, María J.; Calero, Miguel; Medina, Miguel; Mir, Pablo; Sánchez Juan, Pascual; Pastor, Pau; Álvarez, Victoria; Grenier-Boley, Benjamin; Küçükali, Fahri; Van der Lee, Sven; Peters, Oliver; Schneider, Anja; Dichgans, Martin; Rujescu, Dan; Deckert, Jürgen; Düzel, Emrah; Wiltfang, Jens; Wagner, Michael; Grimmer, Timo; Scarmeas, Nikolaos; Moreno, Fermín; Sánchez Valle, Raquel; Real, Luis M.; Rodríguez Rodríguez, Eloy; López de Munain Arregui, Adolfo; Mendonça, Alexandre de; Hort, Jakub; Graff, Caroline; Papenberg, Goran; Giedraitis, Vilmantas; Nordestgaard, Børge G.; Soininen, Hilkka; Kivipelto, Miia; Haapasalo, Annakaisa; Nicolás, Gael; Pasquier, Florence; Hanon, Olivier; Grünblatt, Edna; Galimberti, Daniela; Arosio, Beatrice; Mecocci, Patrizia; Squassina, Alessio; Tremolizzo, Lucio; Rainero, Innocenzo; Seripa, Davide; Williams, Julie; Amouyel, Philippe; Jessen, Frank; Magda, Tsolaki; Frikke-Schmidt, Ruth; Sleegers, Kristel; Engelborghs, Sebastiaan; Vandenberghe, Rik; Ingelsson, Martin; Rossi, Giacomina; Hiltunen, Mikko; Sims, Rebecca; Gugała-Iwaniuk, Magdalena; Lai, Mitchell K. P.; Venketasubramanian, N.; Tan, Boon-Yeow; Cefalù, Angelo Baldassare; Armstrong, Nicola J.; Baschi, Roberta; Bordet, Regis; Bordet, Anne-Marie; Brodaty, Henry; Djurovic, Srdjan; D'Onofrio, Grazia; Esiri, Margaret; Gelé, Patrick; Juárez Cedillo, Teresa; Kalaria, Raj; Karhunen, Pekka; Laczo, Jan; Lerch, Ondrej; Masullo, Carlo; Mather, Karen A.; Matoska, Vaclav; Melkas, Susanna; Monastero, Roberto; Numbers, Katya; Panza, Francesco; Polvikoski, Tuomo M.; Quinn, Joe; Rongve, Arvid; Sachdev, Perminder S.; Scamosci, Michela; Thalamuthu, Anbupalam; Tybjærg-Hansen, Anne; Vyhnalek, Martin; Westaway, Shawn K.; Martinsen, Amy E.; Skogholt, Anne Heidi; Willer, Cristen J.; Stordal, Eystein; Bråthen, Geir; Nielsen, Jonas Bille; Fritsche, Lars G.; Thomas, Laurent F.; Pedersen, Linda M.; Gabrielsen, Maiken E.; Drange, Ole Kristian; Sando, Sigrid Botne; Meisingset, Tore Wergeland; Chene, Genevieve; Zhou, Wei; Tzourio, Christophe; Tin, Adrienne; López, Óscar L.; Mary, Haan; Aiello, Allison E.; Børte, Sigrid; Bosnes, Ingunn; Van Duijn, Cornelia; Cheung, Ching-Lung; Bennett, David A.; Chen, Christopher; Kamboh, M. Ilyas; Satizabal, Claudia; Ikram, M. Kamran; Adams, Hieab; Qiong, Yang; Schellenberg, Gerard D.; Selbæk, Geir; Hveem, Kristian; Andreassen, Ole A.; Ramírez, Alfredo; Dufouil, Carole; Van der Flier, Wiesje; Zwart, John-Anker; Debette, Stéphanie; Fornage, Myriam; Winsvold, Bendik; Lambert, Jean-Charles; Ruiz, Agustín; Kehoe, Patrick G.; Weinstein, Galit; Seshadri, Sudha
    INTRODUCTION: Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD. METHODS: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. RESULTS: For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonance imaging markers of small vessel disease (SVD; HBEGF). Novel VaD loci were associated with hypertension, diabetes, and neuron maintenance (SPRY2, FOXA2, AJAP1, and PSMA3). DISCUSSION: Our study identified genetic risks underlying ACD, demonstrating overlap with neurodegenerative processes, vascular risk factors, and cerebral SVD. Highlights: We conducted the largest genome-wide association study of all-cause dementia (ACD) and vascular dementia (VaD). Known genetic variants associated with AD were replicated for ACD and VaD. Functional analyses identified novel loci for ACD and VaD. Genetic risks of ACD overlapped with neurodegeneration, vascular risk factors, and cerebral small vessel disease.