Impact of chronic pain and depressive symptoms on the quality of life of adults with Chiari Malformation type I: a comparative study

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dc.contributor.authorGarcía Martín, Maitane
dc.contributor.authorAmayra Caro, Imanol
dc.contributor.authorPérez, Manuel
dc.contributor.authorRodríguez Bermejo, Alicia Aurora
dc.contributor.authorSalgueiro, Monika
dc.contributor.authorInfante, Jon
dc.date.accessioned2024-11-08T12:16:29Z
dc.date.available2024-11-08T12:16:29Z
dc.date.issued2024
dc.date.updated2024-11-08T12:16:29Z
dc.description.abstractChiari Malformation type I (CM-I) is a neurological disorder characterized by cerebellar tonsillar herniation. Chronic pain, particularly headaches, is a prevalent symptom in CM-I patients, significantly impacting their quality of life. The objective of this study was to evaluate the perceived quality of life in adults with CM-I and examine the influence of chronic pain and comorbid symptoms on their well-being. 26 CM-I patients (8 with decompressive surgery) and 26 matched healthy controls were recruited. Participants completed the following questionnaires: WHOQOL-BREF, HDI, NDI, OLBPDQ and HADS. CM-I patients exhibited significantly lower scores across all domains of quality of life when compared to healthy controls. Chronic pain, including headache, neck pain, and low back pain, was more pronounced among CM-I patients and demonstrated a significant correlation with depressive symptoms. Notably, after controlling for chronic pain, the differences in quality of life between CM-I patients and controls diminished. The results suggest that chronic pain, especially headaches, and comorbid depressive symptoms exert a substantial impact on the quality of life of CM-I patients. Surgical intervention alone may not fully address these issues, highlighting the importance of considering psychological interventions as part of the comprehensive treatment. Further research with larger samples and pre-post-surgery assessments is needed to validate these findings and explore the potential benefits of psychological therapies in enhancing the quality of life for CM-I patients.en
dc.identifier.citationGarcía, M., Amayra, I., Pérez, M., Rodríguez, A. A., Salgueiro, M., & Infante, J. (2024). Impact of chronic pain and depressive symptoms on the quality of life of adults with Chiari Malformation type I: A comparative study. Intractable and Rare Diseases Research, 13(3), 148-156. https://doi.org/10.5582/IRDR.2024.01010
dc.identifier.doi10.5582/IRDR.2024.01010
dc.identifier.issn2186-361X
dc.identifier.urihttp://hdl.handle.net/20.500.14454/1712
dc.language.isoeng
dc.publisherInternational Advancement Center for Medicine and Health Research Co., Ltd.
dc.subject.otherChiari Malformation type I
dc.subject.otherChronic pain
dc.subject.otherPsychological symptoms
dc.subject.otherQuality of life
dc.titleImpact of chronic pain and depressive symptoms on the quality of life of adults with Chiari Malformation type I: a comparative studyen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage156
oaire.citation.issue3
oaire.citation.startPage148
oaire.citation.titleIntractable and Rare Diseases Research
oaire.citation.volume13
oaire.versionVoR
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