Brain volumes and cortical thickness and associations with cognition in children born extremely preterm

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dc.contributor.authorKvanta, Hedvig
dc.contributor.authorPadilla, Nelly
dc.contributor.authorNosko, Daniela
dc.contributor.authorMårtensson, Gustaf
dc.contributor.authorBroström, Lina
dc.contributor.authorFernández de Gamarra Oca, Lexuri
dc.contributor.authorBolk, Jenny
dc.contributor.authorÅdén, Ulrika
dc.date.accessioned2025-05-19T10:29:31Z
dc.date.available2025-05-19T10:29:31Z
dc.date.issued2025-02
dc.date.updated2025-05-19T10:29:31Z
dc.description.abstractBackground: Children born extremely preterm (EPT) have altered brain volumes and cortical thickness and lower cognition than children born at term. Associations between these have remained largely unexplored, due to the lack of studies focusing on children born EPT. Methods: Children underwent brain magnetic resonance imaging (MRI) at term and/or 10 years and cognitive assessments at 12 years. The study comprised of 42 children born EPT and 29 term-born controls with cognitive data and MRI data at 10 years, 25 children born EPT had MRI data at term age and 20 had longitudinal MRI data. Results: Cognition was positively associated with brain volumes at 10 years, but negatively associated with cortical thickness at 10 years. Most associations between term age brain volumes and cognitive outcomes were non-significant for children born EPT. Growth from term to 10 years in children born EPT was not associated with cognition. Insular volume was positively associated with cognition in children born EPT. Conclusion: Imaging assessments at 10 years had similar associations to cognition in children born EPT and term-born controls. Insular volume could be a biomarker for cognitive outcome. Associations between brain volumetric growth and cognition require further investigation. Impact: This study investigated brain volumes, volumetric growth, and cortical thickness in children born extremely preterm, who have rarely been studied exclusively, and compared the data with term-born controls. In both groups, brain volumes at 10 years were positively associated with cognitive outcome at 12 years, but cortical thickness at 10 years was negatively associated with cognitive outcome at 12 years. Volumetric growth from term age to 10 years was not associated with cognitive outcome in the subset of children born extremely preterm with longitudinal data. Insular volume may be a potential biomarker for cognitive outcome in children born extremely preterm.en
dc.description.sponsorshipThis study was supported by grants from the Swedish Medical Research Council (grant numbers, 2017-03043) (UÅ), the regional agreement on medical training and clinical research (grant number, ALF SLL 20170243) between Stockholm County Council and the Karolinska Institutet (UÅ), the Swedish Order of Freemasons in Stockholm (NP), the Swedish Medical Society (UÅ), the Swedish Brain Foundation (grant number, FO2019-0045) (UÅ), the Sällskapet Barnavård. Region Stockholm (clinical postdoctorial appointment) (JB). This study was funded by Region Stockholm (combined clinical residency and PhD training program) (HK)en
dc.identifier.citationKvanta, H., Padilla, N., Nosko, D., Mårtensson, G., Broström, L., de Gamarra-Oca, L. F., Bolk, J., & Ådén, U. (2025). Brain volumes and cortical thickness and associations with cognition in children born extremely preterm. Pediatric Research, 97(2), 655-663. https://doi.org/10.1038/S41390-024-03480-1
dc.identifier.doi10.1038/S41390-024-03480-1
dc.identifier.eissn1530-0447
dc.identifier.issn0031-3998
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2766
dc.language.isoeng
dc.publisherSpringer Nature
dc.rights© The Author(s) 2024
dc.titleBrain volumes and cortical thickness and associations with cognition in children born extremely pretermen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage663
oaire.citation.issue2
oaire.citation.startPage655
oaire.citation.titlePediatric Research
oaire.citation.volume97
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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