Long-term neurodevelopmental outcomes after moderate and late preterm birth: a systematic review

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dc.contributor.authorFernández de Gamarra Oca, Lexuri
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorGómez-Gastiasoro, Ainara
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorGarcía Guerrero, Acebo
dc.contributor.authorLoureiro González, Begoña
dc.contributor.authorZubiaurre Elorza, Leire
dc.date.accessioned2025-01-14T12:12:44Z
dc.date.available2025-01-14T12:12:44Z
dc.date.issued2021-10
dc.date.updated2025-01-14T12:12:44Z
dc.description.abstractObjective: To systematically review and perform meta-analyses on the long-term neurodevelopmental outcomes of adults born moderate and late preterm (MLPT) in relation to cognitive functioning and psychiatric disorders. Study design: A search was conducted to identify any studies that involved prematurity in adulthood. From these studies, reports that included a group of MLPT adults and included description of cognitive and/or mental health domains (including specific long-term outcomes) were selected. Results: In total, 155 publications were identified, but only 16 papers met the inclusion criteria. A small effect size (g = 0.38) was found in MLPT to demonstrate poorer intellectual performance compared with those born at term. Moreover, MLPT adults exhibited greater odds for any psychiatric (OR 1.14), substance use (OR 1.16), mood (OR 1.06), and psychotic disorders (OR 1.40). Conclusions: Despite inconsistency due to the methodologic differences between the selected studies, MLPT showed minor long-term effects into adulthood. However, more studies are needed, because prematurity seems to confer some vulnerability to biological and environmental factors that enhance susceptibility to adverse neurodevelopment outcomes.en
dc.description.sponsorshipSupported by the Spanish Ministry of Science, Innovation and Universities (PSI2017-83657-P [to L.Z.-E.]); and Department of Education of the Basque Government (PRE_2019_1_0105 [to L.F.G.-O.]; A-grade Team: IT946-16 [to N.O.])en
dc.identifier.citationFernández de Gamarra-Oca, L., Ojeda, N., Gómez-Gastiasoro, A., Peña, J., Ibarretxe-Bilbao, N., García-Guerrero, M. A., Loureiro, B., & Zubiaurre-Elorza, L. (2021). Long-Term Neurodevelopmental Outcomes after Moderate and Late Preterm Birth: A Systematic Review. Journal of Pediatrics, 237, 168-176. https://doi.org/10.1016/J.JPEDS.2021.06.004
dc.identifier.doi10.1016/J.JPEDS.2021.06.004
dc.identifier.eissn1097-6833
dc.identifier.issn0022-3476
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2218
dc.language.isoeng
dc.publisherMosby Inc.
dc.rights© 2021 The Author(s)
dc.subject.otherCognition
dc.subject.otherLong-term effects
dc.subject.otherMental health
dc.subject.otherModerate and late prematurity
dc.titleLong-term neurodevelopmental outcomes after moderate and late preterm birth: a systematic reviewen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage176.e11
oaire.citation.startPage168
oaire.citation.titleJournal of Pediatrics
oaire.citation.volume237
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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