Clinical and psychological disturbances of myasthenia gravis: how anxiety, sleep quality, and thymectomy interact

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dc.contributor.authorGarcía Sanchoyerto, Maddalen
dc.contributor.authorAmayra Caro, Imanol
dc.contributor.authorRuiz de Lazcano Sánchez, Aitana
dc.contributor.authorRodríguez Bermejo, Alicia Aurora
dc.contributor.authorAnguiano, Samuel
dc.contributor.authorSalgueiro, Monika
dc.date.accessioned2025-02-24T09:15:57Z
dc.date.available2025-02-24T09:15:57Z
dc.date.issued2024-12
dc.date.updated2025-02-24T09:15:57Z
dc.description.abstractBackground: Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by fatigue and muscle weakness. Previous research has noted a high incidence of psychological problems, particularly anxiety and depression, as well as alterations in sleep quality among patients with MG. The aim of this study was to assess depression, anxiety, sleep problems, and fatigue in individuals with MG and to analyze the relationships among these variables, as well as to determine the influence of corticosteroid use and thymectomy. Methods: The sample consisted of 72 participants, 42 belonging to the clinical group with MG and 30 healthy participants to the control group. The instruments used were Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI), and Fatigue Severity Scale (FSS). Results: The results showed that MG patients exhibited higher levels of fatigue, anxiety, depression, and poorer sleep quality compared to the control group (p < 0.05). Significant differences in sleep quality and anxiety levels were observed between thymectomized and non-thymectomized patients. Additionally, a positive correlation was found between anxiety symptoms and sleep quality. Conclusions: The study demonstrated the presence of anxious and depressive symptoms in patients with MG, as well as poorer sleep quality and increased fatigue, suggesting that MG affects not only neuromuscular function but also the psychological well-being of patients.en
dc.description.sponsorshipThis research was funded by the Deusto International Research School (DIRS) ‘Programa de Ayudas para Formación de Personal Investigador de la Universidad de Deusto’ [FPI UD_2022_03to M.G.S.]en
dc.identifier.citationGarcía-Sanchoyerto, M., Amayra, I., Ruiz de Lazcano, A., Rodríguez, A. A., Anguiano, S., & Salgueiro, M. (2024). Clinical and Psychological Disturbances of Myasthenia Gravis: How Anxiety, Sleep Quality, and Thymectomy Interact. Psychology International, 6(4), 977-985. https://doi.org/10.3390/PSYCHOLINT6040061
dc.identifier.doi10.3390/PSYCHOLINT6040061
dc.identifier.eissn2813-9844
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2359
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rights© 2024 by the authors
dc.subject.otherMyasthenia gravis
dc.subject.otherPsychological impact
dc.subject.otherSleep impairment
dc.subject.otherFatigue
dc.subject.otherEmotional wellbeing
dc.titleClinical and psychological disturbances of myasthenia gravis: how anxiety, sleep quality, and thymectomy interacten
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage985
oaire.citation.issue4
oaire.citation.startPage977
oaire.citation.titlePsychology International
oaire.citation.volume6
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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