Retinal thickness predicts the risk of cognitive decline in Parkinson disease

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dc.contributor.authorMurueta-Goyena Larrañaga, Ane
dc.contributor.authorPino, Rocío del
dc.contributor.authorGaldos Iztueta, Marta
dc.contributor.authorArana Larrea, Begoña
dc.contributor.authorAcera Gil, María Ángeles
dc.contributor.authorCarmona Abellán, Mar
dc.contributor.authorFernández Valle, Tamara
dc.contributor.authorTijero Merino, Beatriz
dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorCortés, Jesús
dc.contributor.author Ayala Fernández, Unai
dc.contributor.authorBarrenechea Carrasco, Maitane
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorGabilondo Cuellar, Iñigo
dc.date.accessioned2025-04-29T13:28:20Z
dc.date.available2025-04-29T13:28:20Z
dc.date.issued2021-01
dc.date.updated2025-04-29T13:28:19Z
dc.description.abstractObjective: This study was undertaken to analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD). Methods: Patients with Lewy body diseases were enrolled and prospectively evaluated at 3 years, including patients with iPD (n = 42), dementia with Lewy bodies (n = 4), E46K-SNCA mutation carriers (n = 4), and controls (n = 17). All participants underwent Spectralis retinal optical coherence tomography and Montreal Cognitive Assessment, and Unified Parkinson's Disease Rating Scale score was obtained in patients. Macular ganglion cell–inner plexiform layer complex (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness reduction rates were estimated with linear mixed models. Risk ratios were calculated to evaluate the association between baseline GCIPL and pRNFL thicknesses and the risk of subsequent cognitive and motor worsening, using clinically meaningful cutoffs. Results: GCIPL thickness in the parafoveal region (1- to 3-mm ring) presented the largest reduction rate. The annualized atrophy rate was 0.63μm in iPD patients and 0.23μm in controls (p < 0.0001). iPD patients with lower parafoveal GCIPL and pRNFL thickness at baseline presented an increased risk of cognitive decline at 3 years (relative risk [RR] = 3.49, 95% confidence interval [CI] = 1.10–11.1, p = 0.03 and RR = 3.28, 95% CI = 1.03–10.45, p = 0.045, respectively). We did not identify significant associations between retinal thickness and motor deterioration. Interpretation: Our results provide evidence of the potential use of optical coherence tomography–measured parafoveal GCIPL thickness to monitor neurodegeneration and to predict the risk of cognitive worsening over time in iPDen
dc.description.sponsorshipThis study was cofunded by the Michael J. Fox Foundation (RRIA [Rapid Response Innovation Awards] 2014 Program, grant ID: 10189), the Carlos III Health Institute, and the European Union (ERDF/ESF, “A Way to Make Europe”/“Investing in Your Future”) through the projects PI14/00679 and PI16/00005; the Juan Rodes grant JR15/00008 (I.G.); and the Department of Health of the Basque Government through the projects 2016111009 and 2020333033en
dc.identifier.citationMurueta-Goyena, A., Del Pino, R., Galdós, M., Arana, B., Acera, M., Carmona-Abellán, M., Fernández-Valle, T., Tijero, B., Lucas-Jiménez, O., Ojeda, N., Ibarretxe-Bilbao, N., Peña, J., Cortes, J., Ayala, U., Barrenechea, M., Gómez-Esteban, J. C., & Gabilondo, I. (2021). Retinal thickness predicts the risk of cognitive decline in Parkinson disease. Annals of Neurology, 89(1), 165-176. https://doi.org/10.1002/ANA.25944
dc.identifier.doi10.1002/ANA.25944
dc.identifier.eissn1531-8249
dc.identifier.issn0364-5134
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2637
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc
dc.rights© 2020 The Authors
dc.titleRetinal thickness predicts the risk of cognitive decline in Parkinson diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage176
oaire.citation.issue1
oaire.citation.startPage165
oaire.citation.titleAnnals of Neurology
oaire.citation.volume89
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc/4.0/
oaire.versionVoR
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