Subclinical bowel inflammation increases healthcare resources utilization and steroid use before diagnosis of inflammatory bowel disease

Vista sencilla de ítem
dc.contributor.authorRodríguez Lago, Iago
dc.contributor.authorAguirre Larracoechea, Urko
dc.contributor.authorRamírez de la Piscina, Patricia
dc.contributor.authorMuñagorri, Ana I.
dc.contributor.authorZapata, Eva
dc.contributor.authorHiguera, Rebeca
dc.contributor.authorMontalvo, Isabel
dc.contributor.authorIriarte, Ainara
dc.contributor.authorFernández Calderón, María
dc.contributor.authorArreba González, Paz
dc.contributor.authorCarrascosa, Juan
dc.contributor.authorCabriada, José Luis
dc.contributor.authorBarreiro de Acosta, Manuel
dc.date.accessioned2025-06-19T13:49:25Z
dc.date.available2025-06-19T13:49:25Z
dc.date.issued2023-02
dc.date.updated2025-06-19T13:49:25Z
dc.description.abstractBackground: Previous data support that the inflammatory process underlying ulcerative colitis (UC) and Crohn's disease (CD) can start years before the diagnosis. The aim of this study was to determine if patients with an incidental diagnosis of UC or CD demonstrate an increase in healthcare utilization in the years preceding the symptomatic onset of the disease. Methods: We performed a multicenter, retrospective, hospital-based, case-control study. Patients with an incidental diagnosis of UC or CD during the colorectal cancer screening program at 9 hospitals were included. Cases were matched 1:3 and compared separately with two control populations: one including healthy non-IBD subjects adjusted by gender, age, and date, excluding those with visits to Gastroenterology; and a second control cohort of UC/CD patients with symptomatic onset. Results: A total of 124 patients with preclinical inflammatory bowel disease (IBD) were included (87 UC, 30 CD, 7 IBD unclassified; median age 56 years). Patients with preclinical IBD showed an increase in the number of visits to Primary Care up to 3 and 5 years before diagnosis (aIRR 1.59, 95% CI [1.37–1.86], p = 0.001; aIRR 1.43, 95% CI [1.24–1.67], p = 0.01) and more frequent use of steroids (aOR 2.84, 95% CI [1.21–6.69], p = 0.03; aOR 2.25, 95% CI [1.06–4.79], p = 0.04) compared to matched non-IBD healthy controls, respectively. In contrast, patients with a symptomatic onset visited Primary Care less frequently, but they had an increase in the number of visits to Emergency Department, specialist care, sick-leaves, CT/ultrasound examinations, and use of antibiotics or systemic steroids. Conclusions: There is an increased need for medical assistance and use of systemic steroids during the presymptomatic phase of IBD. These results will help in establishing new tools for early identification of IBD in the future.en
dc.description.sponsorshipGobierno Vasco‐Eusko Jaurlaritza, Grant/Award Number: 2020222004en
dc.identifier.citationRodríguez-Lago, I., Aguirre, U., Ramírez de la Piscina, P., Muñagorri, A., Zapata, E., Higuera, R., Montalvo, I., Iriarte, A., Fernández-Calderón, M., Arreba, P., Carrascosa, J., Cabriada, J. L., & Barreiro-de Acosta, M. (2023). Subclinical bowel inflammation increases healthcare resources utilization and steroid use before diagnosis of inflammatory bowel disease. United European Gastroenterology Journal, 11(1), 9-18. https://doi.org/10.1002/UEG2.12352
dc.identifier.doi10.1002/UEG2.12352
dc.identifier.eissn2050-6414
dc.identifier.issn2050-6406
dc.identifier.urihttp://hdl.handle.net/20.500.14454/3104
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc
dc.rights© 2022 The Authors
dc.subject.otherCrohn's disease
dc.subject.otherDiagnostic tests
dc.subject.otherEarly
dc.subject.otherPrimary care
dc.subject.otherUlcerative colitis
dc.titleSubclinical bowel inflammation increases healthcare resources utilization and steroid use before diagnosis of inflammatory bowel diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage18
oaire.citation.issue1
oaire.citation.startPage9
oaire.citation.titleUnited European Gastroenterology Journal
oaire.citation.volume11
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
rodriguez_subclinical_2023.pdf
Tamaño:
412.39 KB
Formato:
Adobe Portable Document Format
Descargar
Colecciones
Artículos