A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease

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dc.contributor.authorOltra, Javier
dc.contributor.authorSegura, Barbara
dc.contributor.authorStrafella, Antonio P.
dc.contributor.authorEimeren, Thilo van
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorDíez Cirarda, María
dc.contributor.authorEggers, Carsten
dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorMonté Rubio, Gemma Cristina
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorRuppert, Marina C.
dc.contributor.authorSala Llonch, Roser
dc.contributor.authorTheis, Hendrik
dc.contributor.authorUribe, Carme
dc.contributor.authorJunqué i Plaja, Carme
dc.date.accessioned2025-03-31T13:31:52Z
dc.date.available2025-03-31T13:31:52Z
dc.date.issued2024-12
dc.date.updated2025-03-31T13:31:52Z
dc.description.abstractClinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex differences in cortical gray matter measures in early drug naïve patients have been described, little is known about differences in cortical thickness (CTh) as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58 ± 8.44 years old; mean disease duration 6.42 ± 5.11 years) and 86 healthy controls (50% males; mean age 65.49 ± 9.33 years old) with available T1-weighted 3 T MRI data from four international research centers. Sex differences in regional mean CTh estimations were analyzed using generalized linear models. The relation of CTh in regions showing sex differences with age, disease duration, and age of onset was examined through multiple linear regression. PD males showed thinner cortex than PD females in six frontal (bilateral caudal middle frontal, bilateral superior frontal, left precentral and right pars orbitalis), three parietal (bilateral inferior parietal and left supramarginal), and one limbic region (right posterior cingulate). In PD males, lower CTh values in nine out of ten regions were associated with longer disease duration and older age, whereas in PD females, lower CTh was associated with older age but with longer disease duration only in one region. Overall, male patients show a more widespread pattern of reduced CTh compared with female patients. Disease duration seems more relevant to explain reduced CTh in male patients, suggesting worse prognostic over time. Further studies should explore sex-specific cortical atrophy trajectories using large longitudinal multi-site dataen
dc.description.sponsorshipThis publication is part of the R&D project/grant PID2020-114640GB-I00 funded by MICIU/AEI/10.13039/501100011033. This study was sponsored by Generalitat de Catalunya (SGR 2021SGR00801) and supported by María de Maeztu Unit of Excellence (Institute of Neurosciences, University of Barcelona) CEX2021-001159-M, The Spanish Ministry of Science and Innovation. JO was supported by a fellowship from the Spanish Ministry of Science, Innovation, and Universities, co-financed by the European Social Fund (PRE2018-086675). HT was supported by the Cologne Clinician Scientist Program (CCSP, Faculty of Medicine, University of Cologne), funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (Project No. 413543196). APS is supported by the Canadian Institutes of Health Research (CIHR) (PJT-173540) and the Krembil-Rossy Chair programen
dc.identifier.citationOltra, J., Segura, B., Strafella, A. P., van Eimeren, T., Ibarretxe-Bilbao, N., Diez-Cirarda, M., Eggers, C., Lucas-Jiménez, O., Monté-Rubio, G. C., Ojeda, N., Peña, J., Ruppert, M. C., Sala-Llonch, R., Theis, H., Uribe, C., & Junque, C. (2024). A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease. npj Parkinson’s Disease, 10(1). https://doi.org/10.1038/S41531-024-00686-2
dc.identifier.doi10.1038/S41531-024-00686-2
dc.identifier.eissn2373-8057
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2594
dc.language.isoeng
dc.publisherNature Research
dc.rights© The Author(s) 2024
dc.titleA multi-site study on sex differences in cortical thickness in non-demented Parkinson’s diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue1
oaire.citation.titlenpj Parkinson's Disease
oaire.citation.volume10
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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