Social cognition in DMD and BMD dystrophinopathies: a cross-sectional preliminary study

dc.contributor.authorGarcía Urquiza, Irune
dc.contributor.authorMartínez, Óscar
dc.contributor.authorLópez Paz, Juan Francisco
dc.contributor.authorGarcía Martín, Maitane
dc.contributor.authorEspinosa Blanco, Patricia
dc.contributor.authorRodríguez Bermejo, Alicia Aurora
dc.contributor.authorPallarès-Sastre, Mercè
dc.contributor.authorRuiz de Lazcano Sánchez, Aitana
dc.contributor.authorAmayra Caro, Imanol
dc.date.accessioned2024-11-19T14:37:38Z
dc.date.available2024-11-19T14:37:38Z
dc.date.issued2024
dc.date.updated2024-11-19T14:37:38Z
dc.description.abstractObjective: The dystrophinopathies called Duchenne and Becker muscular dystrophies (DMD/BMD) are rare, progressive, incurable, and life-limiting paediatric-onset neuromuscular diseases. These diseases have long been associated with specific neuropsychological deficits. However, the performance of these patients in the social cognition domain has not been properly investigated. Thus, the main objective of this study was to compare the performance on social cognition between DMD/BMD patients and healthy age-matched boys. Method: This cross-sectional study included 20 DMD/BMD children and adolescents and 20 healthy controls. The protocol included the Social Perception Domain of the NEPSY-II, the Reading the Mind in the Eyes Test–Child and Happé’s Strange Stories test. General intelligence was controlled to eliminate the possible influence of covariables. All the assessments were performed remotely. Results: Most social cognition tasks were worse in patients with DMD/BMD than in matched healthy controls. These differences remained even after controlling for the general intelligence variable, with the exception of Total Disgust Errors (F = 1.462, p =.234, η2p=.038) and Verbal task (F = 1.820, p =.185, η2p=.047) scores from the NEPSY-II. Conclusions: This is the first study to demonstrate that the neuropsychological domain of social cognition is impaired in DMD/BMD patients, independent of the level of general intelligence. Screening assessments in DMD/BMD patients should be promoted to allow social cognition difficulties to be detected at an early stage to enhance patients’ quality of life and social development.en
dc.description.sponsorshipThis study was funded by a grant from the Deusto International Research School (DIRS) ‘Programa de Ayudas para Formación de Personal Investigador de la universidad de Deusto’ (FPI uD_2021_04 to Irune García)en
dc.identifier.citationGarcía, I., Martínez, O., López-Paz, J. F., García, M., Espinosa-Blanco, P., Rodríguez, A. A., Pallarès-Sastre, M., Ruiz de Lazcano, A., & Amayra, I. (2024). Social cognition in DMD and BMD dystrophinopathies: A cross-sectional preliminary study. Clinical Neuropsychologist, 38(1), 219-234. https://doi.org/10.1080/13854046.2023.2202332
dc.identifier.doi10.1080/13854046.2023.2202332
dc.identifier.eissn1744-4144
dc.identifier.urihttp://hdl.handle.net/20.500.14454/1982
dc.language.isoeng
dc.publisherRoutledge
dc.rights© 2023 Informa UK Limited, trading as Taylor & Francis Group
dc.subject.otherBMD
dc.subject.otherDMD
dc.subject.otherDystrophinopathies
dc.subject.otherGeneral intelligence
dc.subject.otherSocial cognition
dc.titleSocial cognition in DMD and BMD dystrophinopathies: a cross-sectional preliminary studyen
dc.typejournal article
dcterms.accessRightsmetadata only access
oaire.citation.endPage234
oaire.citation.issue1
oaire.citation.startPage219
oaire.citation.titleClinical Neuropsychologist
oaire.citation.volume38
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