Contributions of sex, depression, and cognition on brain connectivity dynamics in Parkinson’s disease

Vista sencilla de ítem
dc.contributor.authorDíez Cirarda, María
dc.contributor.authorGabilondo Cuellar, Iñigo
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorKim, Jinhee
dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorPino, Rocío del
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorMihaescu, Alexander
dc.contributor.authorValli, Mikaeel
dc.contributor.authorAcera Gil, María Ángeles
dc.contributor.authorCabrera Zubizarreta, Alberto
dc.contributor.authorGómez Beldarrain, María Ángeles
dc.contributor.authorStrafella, Antonio P.
dc.date.accessioned2025-06-14T07:46:14Z
dc.date.available2025-06-14T07:46:14Z
dc.date.issued2021-12-16
dc.date.updated2025-06-14T07:46:13Z
dc.description.abstractAlterations in time-varying functional connectivity (FC) have been found in Parkinson’s disease (PD) patients. To date, very little is known about the influence of sex on brain FC in PD patients and how this could be related to disease severity. The first objective was to evaluate the influence of sex on dynamic FC characteristics in PD patients and healthy controls (HC), while the second aim was to investigate the temporal patterns of dynamic connectivity related to PD motor and non-motor symptoms. Ninety-nine PD patients and sixty-two HC underwent a neuropsychological and clinical assessment. Rs-fMRI and T1-weighted MRI were also acquired. Dynamic FC analyses were performed in the GIFT toolbox. Dynamic FC analyses identified two States: State I, characterized by within-network positive coupling; and State II that showed between-network connectivity, mostly involving somatomotor and visual networks. Sex differences were found in dynamic indexes in HC but these differences were not observed in PD. Hierarchical clustering analysis identified three phenotypically distinct PD subgroups: (1) Subgroup A was characterized by mild motor symptoms; (2) Subgroup B was characterized by depressive and motor symptoms; (3) Subgroup C was characterized by cognitive and motor symptoms. Results revealed that changes in the temporal properties of connectivity were related to the motor/non-motor outcomes of PD severity. Findings suggest that while in HC sex differences may play a certain role in dynamic connectivity patterns, in PD patients, these effects may be overcome by the neurodegenerative process. Changes in the temporal properties of connectivity in PD were mainly related to the clinical markers of PD severity.en
dc.description.sponsorshipThis study was supported by the Canadian Institutes of Health Research (PJ8 169695) to A.P.S.; Michael J. Fox Foundation (2014 Rapid Response Innovation Awards; Grant 10189), Carlos III Health Institute through Projects PI14/00679 and PI16/00005 (cofunded by the European Regional Development Fund/European Social Fund “Investing in Your Future”), and by the Department of Health of the Basque Government through Project 2016111009 to J.C.G.-E. and I.G.; Department of Health of the Basque Government [2011111117] and the Spanish Ministry of Economy and Competitiveness [PSI2012-32441] to N.I.-B.; M.D.-C. received a Post-doctoral research improvement fellowship from the Basque Government [POS_2018_1_0008]. A.P.S. is supported by the Canada Research Chair Program and R. Thomson Foundationen
dc.identifier.citationDiez-Cirarda, M., Gabilondo, I., Ibarretxe-Bilbao, N., Gómez-Esteban, J. C., Kim, J., Lucas-Jiménez, O., Del Pino, R., Peña, J., Ojeda, N., Mihaescu, A., Valli, M., Acera, M. A., Cabrera-Zubizarreta, A., Gómez-Beldarrain, M. A., & Strafella, A. P. (2021). Contributions of sex, depression, and cognition on brain connectivity dynamics in Parkinson’s disease. npj Parkinson’s Disease, 7(1). https://doi.org/10.1038/S41531-021-00257-9
dc.identifier.doi10.1038/S41531-021-00257-9
dc.identifier.eissn2373-8057
dc.identifier.urihttp://hdl.handle.net/20.500.14454/3055
dc.language.isoeng
dc.publisherNature Research
dc.rights© The Author(s) 2021
dc.titleContributions of sex, depression, and cognition on brain connectivity dynamics in Parkinson’s diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue1
oaire.citation.titlenpj Parkinson's Disease
oaire.citation.volume7
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
diez_contributions_2021.pdf
Tamaño:
3.58 MB
Formato:
Adobe Portable Document Format
Descargar
Colecciones
Artículos