Hippocampal volumes and cognitive performance in children born extremely preterm with and without low-grade intraventricular haemorrhage

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dc.contributor.authorFernández de Gamarra Oca, Lexuri
dc.contributor.authorKvanta, Hedvig
dc.contributor.authorBroström, Lina
dc.contributor.authorNosko, Daniela
dc.contributor.authorEklöf, E.
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorZubiaurre Elorza, Leire
dc.contributor.authorPadilla, N.
dc.contributor.authorÅdén, Ulrika
dc.date.accessioned2025-01-14T12:12:45Z
dc.date.available2025-01-14T12:12:45Z
dc.date.issued2023-06
dc.date.updated2025-01-14T12:12:45Z
dc.description.abstractChildren born extremely preterm, especially those with intraventricular haemorrhage (IVH), are at increased risk of adverse cognitive outcomes during childhood. The present study aimed to explore the effects of IVH (grades I–II) on hippocampal volumes, and their correlates with cognitive performance. The sample consisted of 94 participants, including 54 children born extremely preterm (19 with IVH, grades I–II), and 40 children born at term. All participants underwent a magnetic resonance imaging study at the age of 10 (Mage = 10.20 years; SDage = 0.78), and 74 of them (45 extremely preterm and 29 full-term) carried out a cognitive assessment at 12 years old. Children born extremely preterm had lower scores in cognitive performance compared to their full-term peers. Significant positive partial correlations were observed between global bilateral hippocampus, left CA-field, and left subiculum volumes with processing speed in the full-term group, while no significant correlations were found in the extremely preterm group. Moderation analyses in the extremely preterm sample revealed that low-grade IVH moderated the relationship between right hippocampal volume and full-IQ (F(4,40) =5.42, p = 0.001, R2 = 0.35). Having greater right hippocampal volume had a protective effect on full-IQ in those children born extremely preterm with low-grade IVH.en
dc.description.sponsorshipOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by grants from the Swedish Medical Research Council (2017–03043) (UÅ), the Regional Agreement on Medical Training and Clinical Research (ALF SLL 20170243) between Stockholm County Council and the Karolinska Institutet (UÅ), the Swedish Order of Freemasons in Stockholm (NP), the Swedish Medical Society (UÅ), the Swedish Brain Foundation (FO2019-0045) (UÅ), the Philipson Foundation (UÅ), and the Department of Education of the Basque Government (PRE_2019_1_0105) (LFG-O).en
dc.identifier.citationFernández de Gamarra-Oca, Kvanta, Broström, Nosko, Eklöf, Ojeda, Zubiaurre-Elorza, Padilla, & Ådén. (2023). Hippocampal volumes and cognitive performance in children born extremely preterm with and without low-grade intraventricular haemorrhage. Brain Structure and Function, 228(5), 1191-1200. https://doi.org/10.1007/S00429-023-02643-W
dc.identifier.doi10.1007/S00429-023-02643-W
dc.identifier.eissn1863-2661
dc.identifier.issn1863-2653
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2219
dc.language.isoeng
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.rights© The Author(s) 2023
dc.subject.otherChildhood
dc.subject.otherCognition
dc.subject.otherExtremely preterm
dc.subject.otherIntraventricular haemorrhage
dc.titleHippocampal volumes and cognitive performance in children born extremely preterm with and without low-grade intraventricular haemorrhageen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage1200
oaire.citation.issue5
oaire.citation.startPage1191
oaire.citation.titleBrain Structure and Function
oaire.citation.volume228
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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