Stereotactic body radiotherapy as a curative treatment for de novo mucosal carcinoma of the head and neck: a feasible alternative option for fragile patients with small lesion: a systematic review

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dc.contributor.authorStrojan, Primož
dc.contributor.authorKokalj, Marko
dc.contributor.authorPlavc, Gaber
dc.contributor.authorNg, Sweet Ping
dc.contributor.authorNuyts, Sandra
dc.contributor.authorChiesa Estomba, Carlos Miguel
dc.contributor.authorEisbruch, Avraham
dc.contributor.authorBree, Remco de
dc.contributor.authorChow, James C. H.
dc.contributor.authorMäkitie, Antti A.
dc.contributor.authorLópez Álvarez, Fernando
dc.contributor.authorSaba, Nabil F.
dc.contributor.authorFerlito,Alfio
dc.date.accessioned2025-05-26T08:45:15Z
dc.date.available2025-05-26T08:45:15Z
dc.date.issued2024-05-31
dc.date.updated2025-05-26T08:45:15Z
dc.description.abstractStereotactic body radiotherapy (SBRT) is characterized by a high dose per fraction, well-defined small targets, superior dose conformity, and a steep off-target dose gradient. A literature search was conducted to examine the experience with SBRT as a curative treatment for newly diagnosed mucosal carcinoma of the head and neck (MCHN). Four retrospective case series and one prospective phase I clinical trial published between 2012 and 2020 described 124 patients. SBRT was mainly performed in older patients with different tumor sites. The median size of the planning target volumes ranged from 5.3 to 41 cm3. Different approaches were used to create margins. In two studies, limited elective nodal irradiation was performed. The equivalent doses used were 60–83.33 Gy delivered in five fractions. Considerable heterogeneity was observed in the radiation dose specification. The incidence of grade ≥3 late toxicity was 0–8.3%, with local and regional control ranging from 73% to 100%. Improved or stable quality of life after SBRT was reported in two studies. Curative-intent SBRT for de novo MCHN appears to be an effective and relatively safe treatment for small tumor targets, preferably without concomitant elective tissue irradiation. Standardization of SBRT practice and well-designed prospective clinical trials are needed to better define the role of SBRT in this setting.en
dc.description.sponsorshipThis research was funded by Slovenian Research and Innovation (ARIS), grant number P3-0307en
dc.identifier.citationStrojan, P., Kokalj, M., Plavc, G., Ng, S. P., Nuyts, S., Chiesa-Estomba, C. M., Eisbruch, A., de Bree, R., Chow, J. C. H., Mäkitie, A. A., Lopez, F., Saba, N. F., & Ferlito, A. (2024). Stereotactic body radiotherapy as a curative treatment for de novo mucosal carcinoma of the head and neck: a feasible alternative option for fragile patients with small lesion: a systematic review [Review of Stereotactic Body Radiotherapy as a Curative Treatment for De Novo Mucosal Carcinoma of the Head and Neck: A Feasible Alternative Option for Fragile Patients with Small Lesion: A Systematic Review †]. Cancers, 16(11). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/CANCERS16112096
dc.identifier.doi10.3390/CANCERS16112096
dc.identifier.eissn2072-6694
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2826
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rights© 2024 by the authors
dc.subject.otherHead and neck cancer
dc.subject.otherLocal control
dc.subject.otherMucosal tumor
dc.subject.otherStereotactic body radiotherapy
dc.subject.otherSurvival
dc.subject.otherToxicity
dc.titleStereotactic body radiotherapy as a curative treatment for de novo mucosal carcinoma of the head and neck: a feasible alternative option for fragile patients with small lesion: a systematic reviewen
dc.typereview
dcterms.accessRightsopen access
oaire.citation.issue11
oaire.citation.titleCancers
oaire.citation.volume16
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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