Roles of the physical environment in health-related quality of life in patients with chronic obstructive pulmonary disease

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dc.contributor.authorMoitra, Subhabrata
dc.contributor.authorForaster, María
dc.contributor.authorArbillaga Etxarri, Ane
dc.contributor.authorMarín, Alicia
dc.contributor.authorBarberan-Garcia, Anael
dc.contributor.authorRodríguez-Chiaradia, Diego A.
dc.contributor.authorBalcells, Eva
dc.contributor.authorKoreny, Maria
dc.contributor.authorTorán-Monserrat, Pere
dc.contributor.authorVall-Casas, Pere
dc.contributor.authorRodríguez-Roisin, Robert
dc.contributor.authorGarcia-Aymerich, Judith
dc.date.accessioned2024-11-11T10:50:00Z
dc.date.available2024-11-11T10:50:00Z
dc.date.issued2022-01
dc.date.updated2024-11-11T10:49:59Z
dc.description.abstractRationale: Many clinical and psychological factors are known to influence the health-related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD). However, research on whether environmental factors, such as air pollution, noise, temperature, and blue/green spaces also influence HRQL in COPD has not been systematically investigated. Objective: To assess the relationship between air pollution, road traffic noise, temperature, and distance to blue/green spaces and respiratory-specific HRQL in COPD. Methods: We used cross-sectional data from a multicenter study in 407 stable mild-to-very severe COPD patients from Barcelona (Catalonia). Patients answered the COPD Assessment Test (CAT) and Clinical COPD Questionnaire (CCQ). Individual residential exposure to air pollutants (nitrogen dioxide [NO2] and particulate matters of varying aerodynamic diameters [PM2.5, PM10, and PM2.5absorbance]), road traffic noise (Lden), and land surface temperature were estimated using long-term averages from land-use regression models, 24-h noise maps, and land surface temperature maps, respectively. We measured residential distances to blue/green spaces from the Urban Atlas. We used mixed-effect negative binomial (for CAT) and linear (for CCQ) regression models, adjusted for potential confounders, with a random effect by center. Results: Of those patients, 85 % were male and had a mean (SD) age of 69 (9) years, CAT score of 12 (7), CCQ-total score of 1.4 (1.0), and post-bronchodilator forced expiratory volume in 1 s (FEV1) of 57 (18) %predicted. We found that NO2 and PM2.5absorbance were associated with worsened CAT and CCQ-mental scores, e.g., 0.15-unit change in CAT score [regression coefficient (β) = 0.15; 95 % confidence interval (CI) = 0.03, 0.26] per interquartile range in NO2 [13.7 μg/m3]. Greater distances to blue/green spaces were associated with worsened CCQ-mental scores [0.08; 0.002, 0.15]. Conclusions: Our study showed that increased air pollution, particularly NO2 and PM2.5absorbance and greater distances to blue/green spaces negatively influence HRQL in COPD patients. These findings have important implications for the WHO promotion to develop healthy cities for our future.en
dc.description.sponsorshipThe study was funded by grants from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (ISCIII, PI11/01283 and PI14/0419), integrated into Plan Estatal I + D + I 2013–2016 and co-funded by ISCIII-Subdirección General de Evaluación y Fomento de la Investigación and Fondo Europeo de Desarrollo Regional (FEDER); Sociedad Española de Neumología y Cirugía Torácica (SEPAR, 147/2011 and 201/2011), Societat Catalana de Pneumologia (Ajuts al millor projecte en fisioteràpia respiratòria 2013). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. We acknowledge the support of the European Respiratory Society Long-Term Research Fellowship awarded to Subhabrata Moitra (LTRF-201701-00088). MF is supported by a Beatriu de Pinós fellowship [2018/8374/I] awarded by the Universities and Research Secretariat of the Catalan Ministry of Business and Knowledgeen
dc.identifier.citationMoitra, S., Foraster, M., Arbillaga-Etxarri, A., Marín, A., Barberan-Garcia, A., Rodríguez-Chiaradia, D. A., Balcells, E., Koreny, M., Torán-Monserrat, P., Vall-Casas, P., Rodríguez-Roisin, R., & Garcia-Aymerich, J. (2022). Roles of the physical environment in health-related quality of life in patients with chronic obstructive pulmonary disease. Environmental Research, 203. https://doi.org/10.1016/J.ENVRES.2021.111828
dc.identifier.doi10.1016/J.ENVRES.2021.111828
dc.identifier.issn1096-0953
dc.identifier.urihttp://hdl.handle.net/20.500.14454/1737
dc.language.isoeng
dc.publisherAcademic Press Inc.
dc.rights© 2021 Elsevier Inc.
dc.subject.otherAir pollution
dc.subject.otherAirflow limitation
dc.subject.otherCOPD
dc.subject.otherEnvironment
dc.subject.otherQuality of life
dc.titleRoles of the physical environment in health-related quality of life in patients with chronic obstructive pulmonary diseaseen
dc.typejournal article
dcterms.accessRightsmetadata only access
oaire.citation.titleEnvironmental Research
oaire.citation.volume203
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