Maximal respiratory pressure reference equations in healthy adults and cut-off points for defining respiratory muscle weakness

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dc.contributor.authorLista-Paz, Ana
dc.contributor.authorLanger, Daniel
dc.contributor.authorBarral-Fernández, Margarita
dc.contributor.authorQuintela del Río, Alejandro
dc.contributor.authorGimeno-Santos, Elena
dc.contributor.authorArbillaga Etxarri, Ane
dc.contributor.authorTorres-Castro, Rodrigo
dc.contributor.authorVilaró Casamitjana, Jordi
dc.contributor.authorVaras de la Fuente, Ana B.
dc.contributor.authorSerrano Veguillas, Cristina
dc.contributor.authorBravo Cortés, Pilar
dc.contributor.authorMartín Cortijo, Concepción
dc.contributor.authorGarcía Delgado, Esther
dc.contributor.authorHerrero-Cortina, Beatriz
dc.contributor.authorValera, José Luis
dc.contributor.authorFregonezi, Guilherme A.F.
dc.contributor.authorGonzález Montañez, Carolina
dc.contributor.authorMartín-Valero, Rocío
dc.contributor.authorFrancín-Gallego, Marina
dc.contributor.authorSanesteban Hermida, Yolanda
dc.contributor.authorGiménez Moolhuyzen, Esther
dc.contributor.authorÁlvarez Rivas, Jorge
dc.contributor.authorRíos-Cortés, Antonio T.
dc.contributor.authorSouto-Camba, Sonia
dc.contributor.authorGonzález-Doniz, Luz
dc.date.accessioned2024-11-11T10:49:52Z
dc.date.available2024-11-11T10:49:52Z
dc.date.issued2023-12
dc.date.updated2024-11-11T10:49:52Z
dc.description.abstractIntroduction: Maximal inspiratory and expiratory pressures (PImax/PEmax) reference equations obtained in healthy people are needed to correctly interpret respiratory muscle strength. Currently, no clear cut-off points defining respiratory muscle weakness are available. We aimed to establish sex-specific reference equations for PImax/PEmax in a large sample of healthy adults and to objectively determine cut-off points for respiratory muscle weakness. Methods: A multicentre cross-sectional study was conducted across 14 Spanish centres. Healthy non-smoking volunteers aged 18–80 years stratified by sex and age were recruited. PImax/PEmax were assessed using uniform methodology according to international standards. Multiple linear regressions were used to obtain reference equations. Cut-off points for respiratory muscle weakness were established by using T-scores. Results: The final sample consisted of 610 subjects (314 females; 48 [standard deviation, SD: 17] years). Reference equations for PImax/PEmax included body mass index and a squared term of the age as independent variables for both sexes (p < 0.01). Cut-off points for respiratory muscle weakness based on T-scores ≥2.5 SD below the peak mean value achieved at a young age were: 62 and 83 cmH2O for PImax and 81 and 109 cmH2O for PEmax in females and males, respectively. Conclusion: These reference values, based on the largest dataset collected in a European population to date using uniform methodology, help identify cut-off points for respiratory muscle weakness in females and males. These data will help to better identify the presence of respiratory muscle weakness and to determine indications for interventions to improve respiratory muscle function.en
dc.description.sponsorshipThis work was funded by a research grant from the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) , project 615/2018 and from The Official College of Physiotherapists from Galicia (CoFiGa) . Margarita Barral-Fernández was awarded a grant by SEPAR to work full-time on this project for 12 months. Funding for open access charge: Universidade da Coruña/CISUGen
dc.identifier.citationLista-Paz, A., Langer, D., Barral-Fernández, M., Quintela-del-Río, A., Gimeno-Santos, E., Arbillaga-Etxarri, A., Torres-Castro, R., Vilaró Casamitjana, J., Varas de la Fuente, A. B., Serrano Veguillas, C., Bravo Cortés, P., Martín Cortijo, C., García Delgado, E., Herrero-Cortina, B., Valera, J. L., Fregonezi, G. A. F., González Montañez, C., Martín-Valero, R., Francín-Gallego, M., et al. (2023). Maximal Respiratory Pressure Reference Equations in Healthy Adults and Cut-off Points for Defining Respiratory Muscle Weakness. Archivos de Bronconeumologia, 59(12), 813-820. https://doi.org/10.1016/J.ARBRES.2023.08.016
dc.identifier.doi10.1016/J.ARBRES.2023.08.016
dc.identifier.issn1579-2129
dc.identifier.urihttp://hdl.handle.net/20.500.14454/1733
dc.language.isoeng
dc.publisherSociedad Espanola de Neumologia y Cirugia Toracica (SEPAR)
dc.rights© 2023 The Author(s)
dc.subject.otherAdults
dc.subject.otherHealthy volunteers
dc.subject.otherMaximal respiratory pressures
dc.subject.otherMuscle strength
dc.subject.otherReference values
dc.subject.otherRespiratory function tests
dc.subject.otherRespiratory muscles
dc.titleMaximal respiratory pressure reference equations in healthy adults and cut-off points for defining respiratory muscle weaknessen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage820
oaire.citation.issue12
oaire.citation.startPage813
oaire.citation.titleArchivos de Bronconeumologia
oaire.citation.volume59
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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