Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample

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dc.contributor.authorFernández de Gamarra Oca, Lexuri
dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorOntañón Garcés , José María
dc.contributor.authorLoureiro Gonzalez, Begoña
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorGarcía Guerrero, Acebo
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorZubiaurre Elorza, Leire
dc.date.accessioned2025-01-14T12:12:42Z
dc.date.available2025-01-14T12:12:42Z
dc.date.issued2024-03
dc.date.updated2025-01-14T12:12:42Z
dc.description.abstractAmygdala atypical volume development and functional connectivity (FC) at small gestational ages (GA) have been found across childhood. This adult-oriented study assesses whether altered amygdala structure and function is present following low-risk preterm birth. T1-weighted and resting-state functional MRI images of 33 low-risk preterm (30–36 weeks’ GA) and 29 full-term (37–42 weeks’ GA) young adults of both sexes, aged between 20 and 32 years old, were analyzed using FreeSurfer (v6.0.0) and Coon Toolbox (v21.a). The social-emotional assessment included Happé’s Strange Stories Test, the Moral Judgment Test, Delay-Discounting Test, Adult Self Report, and Emotion Regulation Questionnaire. No differences were found in social-emotional outcomes or amygdala volumes between the groups. Low-risk preterm young adults showed increased FC between the left amygdala, right amygdala and medial frontal cortex (MedFC) (F = 9.89, p-FWE = 0.009) at cluster level compared to their full-term peers. However, significant results at connection level were not observed between left and right amygdala. Lastly, increased FC at cluster level between the right amygdala and MedFC, and left amygdala and MedFC, was related to better social-emotional outcomes only in low-risk preterm young adults (F = 6.60, p-FWE = 0.036) at cluster level. At connection level, in contrast, only right amygdala–MedFC increased FC was significantly associated with better social-emotional outcomes. This study reveals that low-risk prematurity does not have an effect on social-emotional outcomes or structural amygdala volumes during young adulthood. However, individuals who were considered to be at a lower risk of exhibiting neurodevelopmental alterations following preterm birth demonstrated increased FC between the left and right amygdala and MedFC.en
dc.description.sponsorshipOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This research was supported by the Spanish Ministry of Science, Innovation and Universities [L. Zubiaurre-Elorza (PSI2017-83657-P)]; the Department of Education and Science of the Basque Government [N. Ojeda (IT1545-22)]; and the Department of Education of the Basque Government [L. Fernández de Gamarra-Oca (PRE_2019_1_0105)]en
dc.identifier.citationFernández de Gamarra-Oca, Lucas-Jiménez, Ontañón, Loureiro-Gonzalez, Peña, Ibarretxe-Bilbao, García-Guerrero, Ojeda, & Zubiaurre-Elorza. (2024). Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample. Brain Structure and Function, 229(2), 477-488. https://doi.org/10.1007/S00429-023-02749-1
dc.identifier.doi10.1007/S00429-023-02749-1
dc.identifier.eissn1863-2661
dc.identifier.issn1863-2653
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2217
dc.language.isoeng
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.rights© The Author(s) 2024
dc.subject.otherAmygdala
dc.subject.otherFunctional connectivity
dc.subject.otherLow-risk preterm birth
dc.subject.otherSocial-emotional outcomes
dc.subject.otherYoung adulthood
dc.titleAmygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sampleen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage488
oaire.citation.issue2
oaire.citation.startPage477
oaire.citation.titleBrain Structure and Function
oaire.citation.volume229
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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