Effectiveness of neural mobilisation for the treatment of nerve-related cervicobrachial pain: a systematic review with subgroup meta-analysis

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dc.contributor.authorLascurain-Aguirrebeña, Ion
dc.contributor.authorDominguez, Laura
dc.contributor.authorVillanueva Ruiz, Iker
dc.contributor.authorBallesteros, Javier
dc.contributor.authorRueda-Etxeberria, Mikel
dc.contributor.authorRueda, José Ramón
dc.contributor.authorCasado Zumeta, Xabat
dc.contributor.authorAraolaza Arrieta, Maialen
dc.contributor.authorArbillaga Etxarri, Ane
dc.contributor.authorTampin, Brigitte
dc.date.accessioned2024-11-22T08:54:34Z
dc.date.available2024-11-22T08:54:34Z
dc.date.issued2024-03
dc.date.updated2024-11-22T08:54:34Z
dc.description.abstractNeural mobilisations (NM) have been advocated for the treatment of nerve-related cervicobrachial pain; however, it is unclear what types of patients with nerve-related cervicobrachial pain (if any) may benefit. Medline, Web of Science, Scopus, PeDro, Cinahl, and Cochrane databases were searched from inception until December 2022. Randomised controlled trials were included if they assessed the effectiveness of NM in nerve-related cervicobrachial pain, and outcome measures were pain intensity and/or disability. Studies were classified according to their inclusion/exclusion criteria as radiculopathy, Wainner cluster, Hall, and Elvey cluster or other. Meta-analyses with subgroup analyses were performed. Risk of bias was assessed using Cochrane Rob2 tool. Twenty-seven studies were included. For pain and disability reduction, NM was found to be more effective than no treatment (pooled pain mean difference [MD] = -2.81, 95% confidence interval [CI] = -3.81 to -1.81; pooled disability standardized mean difference = -1.55, 95% CI = -2.72 to -0.37), increased the effectiveness of standard physiotherapy as an adjuvant when compared with standard physiotherapy alone (pooled pain MD = -1.44, 95% CI = -1.98 to -0.89; pooled disability MD = -11.07, 95% CI = -16.38 to -5.75) but was no more effective than cervical traction (pooled pain MD = -0.33, 95% CI = -1.35 to 0.68; pooled disability MD = -10.09, 95% CI = -21.89 to 1.81). For disability reduction, NM was found to be more effective than exercise (pooled MD = -18.27, 95% CI = -20.29 to -17.44). In most comparisons, there were significant differences in the effectiveness of NM between the subgroups. Neural mobilisations was consistently more effective than all alternative interventions (no treatment, traction, exercise, and standard physiotherapy alone) in 13 studies classified as Wainner cluster. PROSPERO registration: CRD42022376087.en
dc.description.sponsorshipThe study was supported by the University of the Basque Country (UPV/EHU) and the University of Deusto. Brigitte Tampin receives grant funding from the Sir Charles Gairdner Hospital and Osborne Park Health Care Group Research Advisory Committee and the Charlies Foundation for Researchen
dc.identifier.citationLascurain-Aguirrebeña, I., Dominguez, L., Villanueva-Ruiz, I., Ballesteros, J., Rueda-Etxeberria, M., Rueda, J.-R., Casado-Zumeta, X., Araolaza-Arrieta, M., Arbillaga-Etxarri, A., & Tampin, B. (2024). Effectiveness of neural mobilisation for the treatment of nerve-related cervicobrachial pain: A systematic review with subgroup meta-analysis. Pain, 165(3), 537-549. https://doi.org/10.1097/J.PAIN.0000000000003071
dc.identifier.doi10.1097/J.PAIN.0000000000003071
dc.identifier.eissn1872-6623
dc.identifier.issn0304-3959
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2080
dc.language.isoeng
dc.publisherLippincott Williams and Wilkins
dc.rights© 2023 International Association for the Study of Pain
dc.subject.otherCervicobrachial pain
dc.subject.otherNeural mobilisation
dc.titleEffectiveness of neural mobilisation for the treatment of nerve-related cervicobrachial pain: a systematic review with subgroup meta-analysisen
dc.typejournal article
dcterms.accessRightsmetadata only access
oaire.citation.endPage549
oaire.citation.issue3
oaire.citation.startPage537
oaire.citation.titlePain
oaire.citation.volume165
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