Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage

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dc.contributor.authorFernández de Gamarra Oca, Lexuri
dc.contributor.authorZubiaurre Elorza, Leire
dc.contributor.authorJunqué i Plaja, Carme
dc.contributor.authorSolana, Elisabeth
dc.contributor.authorSoria Pastor, Sara
dc.contributor.authorVázquez, Élida
dc.contributor.authorDelgado, Ignacio
dc.contributor.authorMacaya Ruiz, Alfons
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPoca Pastor, Maria Antònia
dc.date.accessioned2025-01-14T12:12:40Z
dc.date.available2025-01-14T12:12:40Z
dc.date.issued2021-12
dc.date.updated2025-01-14T12:12:40Z
dc.description.abstractPreterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term effects that GM-IVH have on hippocampal subfields, and their correlates with memory. The sample consisted of 58 participants, including 36 preterm-born (16 with GM-IVH and 20 without neonatal brain injury), and 22 full-term children aged between 6 and 15 years old. All participants underwent a cognitive assessment and magnetic resonance imaging study. GM-IVH children evidenced lower scores in Full Intelligence Quotient and memory measures compared to their low-risk preterm and full-term peers. High-risk preterm children with GM-IVH evidenced significantly lower total hippocampal volumes bilaterally and hippocampal subfield volumes compared to both low-risk preterm and full-term groups. Finally, significant positive correlations between memory and hippocampal subfield volumes were only found in preterm participants together; memory and the right CA-field correlation remained significant after Bonferroni correction was applied (p =.002). In conclusion, memory alterations and both global and regional volumetric reductions in the hippocampus were found to be specifically related to a preterm sample with GM-IVH. Nevertheless, results also suggest that prematurity per se has a long-lasting impact on the association between the right CA-field volume and memory during childhood.en
dc.description.sponsorshipThis study was funded by the Spanish Ministry of Science, Innovation and Universities [P.I.: L. Zubiaurre-Elorza (PSI2017-83657-P)]. L. Fernández de Gamarra-Oca, S. Soria-Pastor, R. L. Zubiaurre-Elorza, and E. Solana hold fellowships from the Basque Government (PRE_2019_1_0105), the Spanish Ministry of Education and Science (AP2005-0047) and (AP2008-0935) and the Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona respectively. We would like to extend special thanks to the families and the children who participated in this study.en
dc.identifier.citationFernández de Gamarra-Oca, L., Zubiaurre-Elorza, L., Junqué, C., Solana, E., Soria-Pastor, S., Vázquez, É., Delgado, I., Macaya, A., Ojeda, N., & Poca, M. A. (2021). Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage. Scientific Reports, 11(1). https://doi.org/10.1038/S41598-021-81802-7
dc.identifier.doi10.1038/S41598-021-81802-7
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2216
dc.language.isoeng
dc.publisherNature Research
dc.rights© The Author(s) 2021
dc.titleReduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhageen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue1
oaire.citation.titleScientific Reports
oaire.citation.volume11
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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