Real-world walking cadence in people with COPD

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dc.contributor.authorDelgado Ortiz, Laura
dc.contributor.authorRanciati, Saverio
dc.contributor.authorArbillaga Etxarri, Ane
dc.contributor.authorBalcells, Eva
dc.contributor.authorBuekers, Joren
dc.contributor.authorDemeyer, Heleen
dc.contributor.authorFrei, Anja
dc.contributor.authorGimeno Santos, Elena
dc.contributor.authorHopkinson, Nicholas S.
dc.contributor.authorJong, Corina de
dc.contributor.authorKarlsson, Niklas
dc.contributor.authorLouvaris, Zafeiris
dc.contributor.authorPalmerini, Luca
dc.contributor.authorPolkey, Michael I.
dc.contributor.authorPuhan, Milo A.
dc.contributor.authorRabinovich, Roberto A.
dc.contributor.authorRodríguez Chiaradía, Diego A.
dc.contributor.authorRodríguez Roisin, Robert
dc.contributor.authorTorán, Pere
dc.contributor.authorVogiatzis, Ioannis
dc.contributor.authorWatz, Henrik
dc.contributor.authorTroosters, Thierry
dc.contributor.authorGarcía Aymerich, Judith
dc.date.accessioned2025-01-22T07:42:52Z
dc.date.available2025-01-22T07:42:52Z
dc.date.issued2024-03
dc.date.updated2025-01-22T07:42:52Z
dc.description.abstractIntroduction The clinical validity of real-world walking cadence in people with COPD is unsettled. Our objective was to assess the levels, variability and association with clinically relevant COPD characteristics and outcomes of real-world walking cadence. Methods We assessed walking cadence (steps per minute during walking bouts longer than 10 s) from 7days’ accelerometer data in 593 individuals with COPD from five European countries, and clinical and functional characteristics from validated questionnaires and standardised tests. Severe exacerbations during a 12-month follow-up were recorded from patient reports and medical registries. Results Participants were mostly male (80%) and had mean±SD age of 68±8 years, post-bronchodilator forced expiratory volume in 1 s (FEV1) of 57±19% predicted and walked 6880±3926 steps·day−1. Mean walking cadence was 88±9 steps·min−1, followed a normal distribution and was highly stable within-person (intraclass correlation coefficient 0.92, 95% CI 0.90–0.93). After adjusting for age, sex, height and number of walking bouts in fractional polynomial or linear regressions, walking cadence was positively associated with FEV1, 6-min walk distance, physical activity (steps·day−1, time in moderate-to-vigorous physical activity, vector magnitude units, walking time, intensity during locomotion), physical activity experience and health-related quality of life and negatively associated with breathlessness and depression (all p<0.05). These associations remained after further adjustment for daily steps. In negative binomial regression adjusted for multiple confounders, walking cadence related to lower number of severe exacerbations during follow-up (incidence rate ratio 0.94 per step·min−1, 95% CI 0.91–0.99, p=0.009). Conclusions Higher real-world walking cadence is associated with better COPD status and lower severe exacerbations risk, which makes it attractive as a future prognostic marker and clinical outcome.en
dc.description.sponsorshipSupport statement: This work was supported by the Mobilise-D project that has received funding from the Innovative Medicines Initiative (IMI) 2 Joint Undertaking ( JU) under grant agreement number 820820. This JU receives support from the European Union’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The content of the current publication reflects the authors’ view, and neither IMI nor the European Union, EFPIA or any Associated Partners are responsible for any use that may be made of the information contained herein. The PROactive project was also funded by the IMI JU under grant agreement number 115011. The Urban Training study was funded by grants from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (ISCIII) (PI11/01283 and PI14/0419), integrated into Plan Estatal I+D+I 2013–2016 and co-funded by ISCIII-Subdirección General de Evaluación y Fomento de la Investigación and Fondo Europeo de Desarrollo Regional, Sociedad Española de Neumología y Cirugía Torácica (147/2011 and 201/ 2011) and Societat Catalana de Pneumologia (Ajuts al millor projecte en fisioteràpia respiratòria 2013). L. Delgado-Ortiz receives funding from the grant “Contratos Predoctorales de Formación en Investigación en Salud (PFIS) 2021 of the AES with Exp. FI21/00113” from ISCIII, and the European Social Fund Plus. H. Demeyer is a postdoctoral fellow of FWO Flanders (Belgium). Funding information for this article has been deposited with the Crossref Funder Registry.en
dc.identifier.citationDelgado-Ortiz, L., Ranciati, S., Arbillaga-Etxarri, A., Balcells, E., Buekers, J., Demeyer, H., Frei, A., Gimeno-Santos, E., Hopkinson, N. S., de Jong, C., Karlsson, N., Louvaris, Z., Palmerini, L., Polkey, M. I., Puhan, M. A., Rabinovich, R. A., Rodríguez Chiaradia, D. A., Rodriguez-Roisin, R., Toran-Montserrat, P., et al. (2024). Real-world walking cadence in people with COPD. ERJ Open Research, 10(2). https://doi.org/10.1183/23120541.00673-2023
dc.identifier.doi10.1183/23120541.00673-2023
dc.identifier.eissn2312-0541
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2233
dc.language.isoeng
dc.publisherEuropean Respiratory Society
dc.rights© The authors 2024
dc.titleReal-world walking cadence in people with COPDen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue2
oaire.citation.titleERJ Open Research
oaire.citation.volume10
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc/4.0/
oaire.versionVoR
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