Predictors of health-related quality of life in Parkinson’s disease: the impact of overlap between health-related quality of life and clinical measures

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dc.contributor.authorSanchez Luengos, Itsasne
dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorGómez Beldarrain, María Ángeles
dc.contributor.authorVázquez Picón, Raquel
dc.contributor.authorFoncea Beti, Nerea
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.date.accessioned2025-05-26T08:23:53Z
dc.date.available2025-05-26T08:23:53Z
dc.date.issued2022-07-16
dc.date.updated2025-05-26T08:23:53Z
dc.description.abstractThis study aimed to determine predictors of health-related quality of life (HRQoL) in Parkinson's disease (PD) and to explore their predictive value before and after controlling overlapping items between HRQoL and clinical variables. One hundred and eight PD patients underwent motor, anxiety, depression, apathy, fatigue, and neurocognition assessment. HRQoL was assessed by the Parkinson’s Disease Questionnaire-39 (PDQ-39). In order to determine predictors of HRQoL in PD, stepwise multiple regression analyses were performed in two ways: before and after removing the emotional well-being dimension from PDQ-39 to control the overlap between depression and anxiety, and HRQoL. HRQoL total index was predicted by anxiety, fatigue, motor symptoms, and depression, explaining 26.9%, 7.2%, 2.8%, and 1.9% of the variance. However, after removing overlapping items, HRQoL total index was predicted by fatigue (16.5%), anxiety (6.1%), motor symptoms (3.9%), and neurocognition (2.5%), but not depression. Regarding HRQoL dimensions, mobility and activities of daily living were predicted by fatigue (19.7% and 5%) and UPDRS-III (4% and 10.2%); emotional well-being by fatigue (7.9%); social support by anxiety (12.2%) and UPDRS-III (8.6%); communication by neurocognition (5.3%) and UPDRS-III (3.4%); cognition by anxiety (10.6%) and bodily discomfort by anxiety (23%) and fatigue (4.1%). These findings showed the importance of identifying and controlling overlapping items of HRQoL and clinical measures to perform an accurate interpretation. HRQoL dimensions showed different predictors before and after controlling the overlap. Based on these results fatigue, anxiety, motor symptoms, and neurocognition, but not depression are the main predictors of HRQoL in PD patients.en
dc.description.sponsorshipBBK foundation (P201902032-12/1284), the Department of Education of the Basque Government (IT946-16) and Research Staff Training Programme Grant from the Basque Government (PRE_2018_1_0379)en
dc.identifier.citationSanchez-Luengos, I., Lucas-Jiménez, O., Ojeda, N., Peña, J., Gómez-Esteban, J. C., Gómez-Beldarrain, M. Á., Vázquez-Picón, R., Foncea-Beti, N., & Ibarretxe-Bilbao, N. (2022). Predictors of health-related quality of life in Parkinson’s disease: the impact of overlap between health-related quality of life and clinical measures. Quality of Life Research, 31(11), 3241-3252. https://doi.org/10.1007/S11136-022-03187-Y
dc.identifier.doi10.1007/S11136-022-03187-Y
dc.identifier.eissn1573-2649
dc.identifier.issn0962-9343
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2823
dc.language.isoeng
dc.publisherSpringer Nature
dc.rights© The Author(s) 2022
dc.subject.otherHRQoL
dc.subject.otherAnxiety
dc.subject.otherDepression
dc.subject.otherFatigue
dc.subject.otherNeurocognition
dc.subject.otherMotor symptoms
dc.titlePredictors of health-related quality of life in Parkinson’s disease: the impact of overlap between health-related quality of life and clinical measuresen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage3252
oaire.citation.issue11
oaire.citation.startPage3241
oaire.citation.titleQuality of Life Research
oaire.citation.volume31
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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