Examinando por Autor "Ibarretxe Bilbao, Naroa"
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Ítem Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample(Springer Science and Business Media Deutschland GmbH, 2024-03) Fernández de Gamarra Oca, Lexuri; Lucas Jiménez, Olaia; Ontañón Garcés , José María; Loureiro Gonzalez, Begoña; Peña Lasa, Javier; Ibarretxe Bilbao, Naroa; García Guerrero, Acebo; Ojeda del Pozo, Natalia; Zubiaurre Elorza, LeireAmygdala atypical volume development and functional connectivity (FC) at small gestational ages (GA) have been found across childhood. This adult-oriented study assesses whether altered amygdala structure and function is present following low-risk preterm birth. T1-weighted and resting-state functional MRI images of 33 low-risk preterm (30–36 weeks’ GA) and 29 full-term (37–42 weeks’ GA) young adults of both sexes, aged between 20 and 32 years old, were analyzed using FreeSurfer (v6.0.0) and Coon Toolbox (v21.a). The social-emotional assessment included Happé’s Strange Stories Test, the Moral Judgment Test, Delay-Discounting Test, Adult Self Report, and Emotion Regulation Questionnaire. No differences were found in social-emotional outcomes or amygdala volumes between the groups. Low-risk preterm young adults showed increased FC between the left amygdala, right amygdala and medial frontal cortex (MedFC) (F = 9.89, p-FWE = 0.009) at cluster level compared to their full-term peers. However, significant results at connection level were not observed between left and right amygdala. Lastly, increased FC at cluster level between the right amygdala and MedFC, and left amygdala and MedFC, was related to better social-emotional outcomes only in low-risk preterm young adults (F = 6.60, p-FWE = 0.036) at cluster level. At connection level, in contrast, only right amygdala–MedFC increased FC was significantly associated with better social-emotional outcomes. This study reveals that low-risk prematurity does not have an effect on social-emotional outcomes or structural amygdala volumes during young adulthood. However, individuals who were considered to be at a lower risk of exhibiting neurodevelopmental alterations following preterm birth demonstrated increased FC between the left and right amygdala and MedFC.Ítem Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial(Nature Research, 2021-12) Sampedro, Agurne; Peña Lasa, Javier; Sánchez Gómez, Pedro Manuel; Ibarretxe Bilbao, Naroa; Gómez Gastiasoro, Ainara; Iriarte Yoller, Nagore; Pavón, Cristóbal; Tous Espelosín, Mikel; Ojeda del Pozo, NataliaThis study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in functional outcomes were explored. The program combined cognitive remediation with social cognitive training and social and functional skill training over 20 weeks. The sample included 94 patients, 47 in the REHACOP group and 47 in the active control group (occupational activities). Significant differences were found between the two groups in change scores of processing speed, working memory, verbal memory (VM), inhibition, theory of mind, emotion processing (EP), figural creative strengths, functional competence, disorganization, excitement, and primary negative symptoms. A mediational analysis revealed that changes in VM, inhibition, and EP partially explained the effect of cognitive remediation on functional competence improvement. This study provides initial evidence of the effect of integrative cognitive remediation on primary negative symptoms and creativity.Ítem The effect of changing the balance between right and left dorsolateral prefrontal cortex on different creativity tasks: a transcranial random noise stimulation study(Creative Education Foudation, 2021-12) Peña Lasa, Javier; Sampedro, Agurne; Gómez-Gastiasoro, Ainara; Ibarretxe Bilbao, Naroa; Zubiaurre Elorza, Leire; Aguiar, Covadonga; Ojeda del Pozo, NataliaTranscranial random noise stimulation (tRNS) increases performance in some perceptual tasks. However, little is known about its effect on creativity. Although dorsolateral prefrontal cortex (DLPFC) has been postulated as an important cortical area related to creativity, the relative role of left and right DLPFC is still unclear. We aimed to compare the effect of anodal left/cathodal right (L + R−) and cathodal left/anodal right (L − R+) tRNS over the DLPFC. Eighty-four participants were randomly assigned to L + R−, L−R+ or sham group. Current was set at 2 mA (100–500 Hz) with a 1 mA direct current offset (20 min). Creativity was assessed before and during tRNS with the Remotes Associates Test (RAT), Unusual Uses (UU) and Picture Completion (PC) from Torrance Test of Creative Thinking, nine-dot problem and matchstick arithmetic problems. Bootstrapped analysis of covariance (under-stimulation scores controlling for baseline) showed that L + R− and L − R+ groups had higher scores than sham in UU whereas only L + R− improved in RAT compared to sham. The L − R+ group performed significantly better than L + R− and sham groups in PC, nine-dot problem and matchstick arithmetic problems. L + R− DLPFC may help verbal creative thinking whereas the L − R + seems to produce a “releasing effect” through insight problem solving and originality.Ítem Effects of transcranial electrical stimulation techniques on second and foreign language learning enhancement in healthy adults: a systematic review and meta-analysis(Elsevier Ltd, 2021-09-17) Balboa Bandeira, Yolanda; Zubiaurre Elorza, Leire; Ibarretxe Bilbao, Naroa; Ojeda del Pozo, Natalia; Peña Lasa, JavierBackground: Transcranial electrical stimulation (tES) techniques have been used to enhance different cognitive domains such as language in healthy adults. While several reviews and meta-analysis have been conducted on the effects of tES on different language skills (picture naming, verbal fluency, word reading), there has been little research conducted to date on the effects of tES on the processes involved in foreign language learning. Objective: A meta-analysis was performed to quantify the effects of tES on foreign language learning processes (non-words, artificial grammar, and foreign languages), focusing on accuracy, response times and 1-week follow-up effects, if reported by the studies. Results: Eleven studies that had sham condition were reviewed. Nine of them were analyzed, including five using within-participant design, and four that employed between-participant design. The final analysis encompassed nine studies with 279 healthy participants. The analysis showed moderate enhancing effects of tES on overall language learning (g = 0.50, 95 % CI [0.29, 0.71], p = .0001). However, results were not significant on follow up data (g = 0.54, 95 % CI [-0.12, 1.20], p = .07), and on response times (g = 0.50, 95 % CI [-0.1, 1.18], p = .10). The effects were significantly moderated by years of education. Conclusions: The results suggest that tES seems to enhance the mechanisms involved in foreign language learning; however, more research is needed to understand the impact scope of these techniques on language learning processes.Ítem Enhancement of divergent creative thinking after transcranial near-infrared photobiomodulation over the default mode network(Routledge, 2024) Peña Lasa, Javier; Muthalib, Makii; Beaty, Roger E.; Sampedro, Agurne; Ibarretxe Bilbao, Naroa; Zubiaurre Elorza, Leire; García Guerrero, Acebo; Cortazar, Ibon; Niso, Mikel; Ojeda del Pozo, NataliaTranscranial photobiomodulation (tPBM) has been used for cognitive enhancement in healthy people. However, its effect on creativity has not been investigated. The default mode network (DMN) is associated with divergent thinking (DT; but not convergent thinking, CT), and also with anxiety, which in turn has been negatively related to creativity. We aimed to use tPBM over the DMN to assess the effect on DT compared to sham. Additionally, we assessed the possible mediating effect of anxiety between tPBM and DT. In this single-blind, between-subjects study, 58 healthy participants were randomly assigned to tPBM or sham group. tPBM was applied using near-infrared light (810 nm, 40 Hz; 50% duty cycle), through light-emitting diode devices combining transcranial plus intranasal PBM over the cortical nodes of the DMN for 20 min (240 J/cm2 in total). DT and CT were assessed before (baseline) and after tPBM with the Unusual Uses (UU), Picture Completion (PC) and Remote Associates test (RAT). ANCOVA (post-stimulation controlling for baseline) results showed that tPBM group had significantly higher scores compared to sham in total UU, PC, and total DT. tPBM may be effective for DT enhancement. The lack of effect on CT reveals a specific link between DMN and DT.Ítem Enhancement of phonemic verbal fluency in multilingual young adults by transcranial random noise stimulation(Elsevier Ltd, 2024-06) Balboa Bandeira, Yolanda; Zubiaurre Elorza, Leire; García Guerrero, Acebo; Ibarretxe Bilbao, Naroa; Ojeda del Pozo, Natalia; Peña Lasa, JavierSeveral studies have analyzed the effects of transcranial direct current stimulation on verbal fluency tasks in non-clinical populations. Nevertheless, the reported effects on verbal fluency are inconsistent. In addition, the effect of other techniques such as transcranial random noise stimulation (tRNS) on verbal fluency enhancement has yet to be studied in healthy multilingual populations. This study aims to explore the effects of tRNS on verbal fluency in healthy multilingual individuals. Fifty healthy multilingual (Spanish, English and Basque) adults were randomly assigned to a tRNS or sham group. Electrodes were placed on the left dorsolateral prefrontal cortex and left inferior frontal gyrus. All participants performed phonemic and semantic verbal fluency tasks before, during (online assessment) and immediately after (offline assessment) stimulation in three different languages. The results showed significantly better performance by participants who received tRNS in the phonemic verbal fluency tasks in Spanish (in the online and offline assessment) and English (in the offline assessment). No differences between conditions were found in Basque nor semantic verbal fluency. These findings suggests that tRNS on the left prefrontal cortex could help improve phonemic, yet not semantic, fluency in healthy multilingual adultsÍtem Enhancing creativity with combined transcranial direct current and random noise stimulation of the left dorsolateral prefrontal cortex and inferior frontal gyrus(John Wiley and Sons Inc, 2023-03) Peña Lasa, Javier; Muthalib, Makii; Sampedro, Agurne; Cardoso-Botelho, Mafalda; Zabala Gómez, Oihana; Ibarretxe Bilbao, Naroa; García Guerrero, Acebo; Zubiaurre Elorza, Leire; Ojeda del Pozo, NataliaCreativity is a fundamental human accomplishment from scientific advances to composing music. The left dorsolateral prefrontal cortex (DLPFC) and inferior frontal gyrus (IFG) are important metacontrol hubs in flexibility and persistence brain states, respectively. Those hubs are related to divergent thinking, insight problem-solving, and convergent thinking. In this double-blind, between-subjects study, 81 healthy participants were randomly assigned to one of three groups (n = 27) that received a combined transcranial direct current stimulation–transcranial random noise stimulation (tDCS-tRNS) protocol with the anode over the left DLPFC and cathode over the left IFG (+DLPFC−IFG), the opposite montage (−DLPFC+IFG), and a sham group (+DLPFC−IFG). Both active tDCS-tRNS groups received 20 min of 1 mA tDCS with 1 mA (100–500 Hz) tRNS. Creativity was assessed before (baseline) and during stimulation with the Unusual Uses, Picture Completion (PC), Remote Association test (RAT), Matchstick Arithmetic (MA), and Nine-dot (ND) problems. Only the +DLPFC−IFG group had significantly higher scores compared with sham in the RAT (p =.009), PC fluency (p =.018), PC originality (p =.007), ND (p =.007), and MA (p =.032). Overall, −DLPFC+IFG had greater scores in all creativity tests compared with sham. Implications from the metacontrol theory are discussed.Ítem The impact of creativity on functional outcome in schizophrenia: a mediational model(Nature Research, 2021-02-26) Sampedro, Agurne ; Peña Lasa, Javier; Sánchez Gómez, Pedro Manuel; Ibarretxe Bilbao, Naroa; Iriarte Yoller, Nagore; Pavón, Cristóbal; Hervella Garcés, Isabel; Tous Espelosín, Mikel; Ojeda del Pozo, NataliaFunctional impairment remains one of the most challenging issues for treatment in schizophrenia. However, previous studies have mainly focused on the negative impact of symptoms excluding variables that could positively impact functional outcome, such as creativity, which is considered an adaptive capacity for real-life problem-solving. This study analyzed the predictive role of creativity on functional outcome in 96 patients with schizophrenia through a mediational model, including sociodemographic, clinical, neurocognitive, and social cognitive variables. Path analysis revealed that creativity significantly mediated the relationship between neurocognition and functional outcome, and that creativity mediated between negative symptoms and functional outcome. Additionally, neurocognition was directly associated with functional outcome and social functioning was associated with creativity. The involvement of creativity in functional outcome could have relevant implications for the development of new interventions. These findings open up a new field of research on additional personal resources as possible factors of functional outcome in schizophrenia and other diseasesÍtem Improvement in creativity after transcranial random noise stimulation (tRNS) over the left dorsolateral prefrontal cortex(Nature Publishing Group, 2019-12) Peña Lasa, Javier; Sampedro, Agurne; Ibarretxe Bilbao, Naroa; Zubiaurre Elorza, Leire; Ojeda del Pozo, NataliaCreativity has previously been shown to improve after the application of direct and alternating current transcranial stimulation over the dorsolateral prefrontal cortex (DLPFC). However, previous studies have not tested whether transcranial random noise stimulation (tRNS) was efficient for this purpose. The aim of this randomized, double-blind, placebo-controlled study was to investigate the effect of tRNS on both verbal convergent and (verbal and visual) divergent thinking during left DLPFC tRNS stimulation. Thirty healthy participants were randomly allocated to either a tRNS active group or a sham group. Each session lasted 20 min and the current was set to 1.5 mA (100–500 Hz). Participants’ verbal convergent thinking was assessed with the Remote Associates Test (RAT). Verbal and visual divergent thinking were respectively measured by using the Unusual Uses and Picture Completion subtests from the Torrance Tests of Creative Thinking. Bootstrapped analysis of variance showed significant differences in the mean change scores between the active tRNS group and the sham group in RAT scores (d = 1.68); unusual uses: fluency (d = 2.29) and originality (d = 1.43); and general creativity (d = 1.45). Visual divergent thinking, in contrast, did not show any significant improvement. Our results suggested that tRNS over the left DLPFC is effective for increasing verbal divergent and convergent thinking.Ítem Long-term brain structural and cognitive outcomes in a low-risk preterm-born sample(Nature Research, 2024-12) Fernández de Gamarra Oca, Lexuri; Ojeda del Pozo, Natalia; Ontañón Garcés , José María; Loureiro González, Begoña; Gómez-Gastiasoro, Ainara; Peña Lasa, Javier; Ibarretxe Bilbao, Naroa; García Guerrero, Acebo; Zubiaurre Elorza, LeirePrematurity has been related to altered brain structure and cognition, and so our aim was to describe them in the absence of major structural brain injury following low-risk preterm birth during adolescence and young adulthood. The sample consisted of 250 participants, 132 of whom were low-risk preterm (30–36 weeks’ gestational age) and 118 were full-term individuals (37–42 weeks’ gestational age), aged between 16 and 38 years old. All participants underwent an extensive neuropsychological assessment. T1- and diffusion-weighted MRI images of 33 low-risk preterm and 31 full-term young adults (20–32 years old) were analyzed. No differences were found in terms of general cognitive functioning score or current socioeconomic status; however, the low-risk preterm group obtained lower scores in phonetic and semantic fluencies, and theory of mind. Significant reductions were identified in the thalamus volume as well as thicker cortex in the inferior temporal gyrus in the low-risk preterm group. Low-risk preterm young adults evidenced greater regional AD and MD compared to the full-term sample; while low-risk preterm group showed lower mean NDI and ODI (FWE-corrected, p < 0.05). Being born preterm is associated with poorer performance in various cognitive domains (i.e., phonetic and semantic fluencies, and theory of mind) later in life, along with differences in normative structural brain development in inferior temporal gyrus and regional white matter microstructure.Ítem Long-term neurodevelopmental outcomes after moderate and late preterm birth: a systematic review(Mosby Inc., 2021-10) Fernández de Gamarra Oca, Lexuri; Ojeda del Pozo, Natalia; Gómez-Gastiasoro, Ainara; Peña Lasa, Javier; Ibarretxe Bilbao, Naroa; García Guerrero, Acebo; Loureiro González, Begoña; Zubiaurre Elorza, LeireObjective: To systematically review and perform meta-analyses on the long-term neurodevelopmental outcomes of adults born moderate and late preterm (MLPT) in relation to cognitive functioning and psychiatric disorders. Study design: A search was conducted to identify any studies that involved prematurity in adulthood. From these studies, reports that included a group of MLPT adults and included description of cognitive and/or mental health domains (including specific long-term outcomes) were selected. Results: In total, 155 publications were identified, but only 16 papers met the inclusion criteria. A small effect size (g = 0.38) was found in MLPT to demonstrate poorer intellectual performance compared with those born at term. Moreover, MLPT adults exhibited greater odds for any psychiatric (OR 1.14), substance use (OR 1.16), mood (OR 1.06), and psychotic disorders (OR 1.40). Conclusions: Despite inconsistency due to the methodologic differences between the selected studies, MLPT showed minor long-term effects into adulthood. However, more studies are needed, because prematurity seems to confer some vulnerability to biological and environmental factors that enhance susceptibility to adverse neurodevelopment outcomes.Ítem Maternal care and general cognitive functioning in moderate and late preterm-born children(Elsevier Ltd, 2022-10) Fernández de Gamarra Oca, Lexuri; Ojeda del Pozo, Natalia; Loureiro González, Begoña; Sierra Ibarbia, Andrea; García Guerrero, Acebo; Peña Lasa, Javier; Ibarretxe Bilbao, Naroa; Zubiaurre Elorza, LeireAim: To establish the neuropsychological profile in moderate and late preterm (MLPT) samples during childhood, and to assess the potential role of early life environmental factors in cognitive outcomes. Methods: One hundred-and-six children took part in this study, including 42 moderate preterm (Mage=11.57 years; Mdage: 12; SDage=1.77), 33 late preterm (Mage=12.21 years; Mdage: 12; SDage=0.78) and 31 full-term children (Mage=11.42 years; Mdage: 12; SDage=1.84). All participants underwent an environmental, emotional-behavioural, life satisfaction, functionality, resilience, and cognitive assessment. Results: Significant differences were found in several cognitive domains among groups. Further, the maternal care measure moderated the relationship between the degree of maturity/immaturity at birth and general cognitive functioning score (F(4,1014101)= 3.72, p = 0.007, R2 = 0.13). Conclusions: The findings showed different neuropsychological profiles during childhood, with the moderate preterm sample reporting lower values. Additionally, the appropriate level of maternal care measure used in this study seems to have had a protective effect on cognitive development.Ítem Moderators of functional improvement after integrative cognitive remediation in schizophrenia: toward a personalized treatment approach(Elsevier Ireland Ltd, 2023-11) Sampedro, Agurne; Peña Lasa, Javier; Sánchez Gómez, Pedro Manuel; Ibarretxe Bilbao, Naroa; Iriarte Yoller, Nagore; Pavón, Cristóbal; Ojeda del Pozo, NataliaCognitive remediation is an effective intervention for improving functional outcome in schizophrenia. However, the factors that moderate this improvement are still poorly understood. The study aimed to identify moderators of functional outcome improvement after integrative cognitive remediation (REHACOP) in schizophrenia. This was a secondary analysis of data from two randomized controlled trials, which included 182 patients (REHACOP group=94; active control group=88). Hierarchical regression analyses were conducted to identify moderators of functional outcome improvement. Two baseline level groups (low-level and high-level) were created to analyze the moderating role of this baseline level cluster using repeated measures ANCOVA. The REHACOP was effective regardless of participants’ baseline level, but regression analyses indicated that the effectiveness on functional outcome was higher among those who were older, had fewer years in education, lower scores in baseline cognition and functional outcome, and more negative symptoms. Repeated measures ANOVA showed that the baseline level cluster influenced the improvement in functional outcome, with the low-level group showing greater improvements. The results reinforced the need to implement cognitive remediation programs more broadly as a treatment for schizophrenia in healthcare services. Furthermore, they provided evidence for the development of personalized cognitive remediation plans to improve benefits in different schizophrenia profiles.Ítem A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease(Nature Research, 2024-12) Oltra, Javier; Segura, Barbara; Strafella, Antonio P.; Eimeren, Thilo van; Ibarretxe Bilbao, Naroa; Díez Cirarda, María; Eggers, Carsten; Lucas Jiménez, Olaia; Monté Rubio, Gemma Cristina; Ojeda del Pozo, Natalia; Peña Lasa, Javier; Ruppert, Marina C.; Sala Llonch, Roser; Theis, Hendrik; Uribe, Carme; Junqué i Plaja, CarmeClinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex differences in cortical gray matter measures in early drug naïve patients have been described, little is known about differences in cortical thickness (CTh) as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58 ± 8.44 years old; mean disease duration 6.42 ± 5.11 years) and 86 healthy controls (50% males; mean age 65.49 ± 9.33 years old) with available T1-weighted 3 T MRI data from four international research centers. Sex differences in regional mean CTh estimations were analyzed using generalized linear models. The relation of CTh in regions showing sex differences with age, disease duration, and age of onset was examined through multiple linear regression. PD males showed thinner cortex than PD females in six frontal (bilateral caudal middle frontal, bilateral superior frontal, left precentral and right pars orbitalis), three parietal (bilateral inferior parietal and left supramarginal), and one limbic region (right posterior cingulate). In PD males, lower CTh values in nine out of ten regions were associated with longer disease duration and older age, whereas in PD females, lower CTh was associated with older age but with longer disease duration only in one region. Overall, male patients show a more widespread pattern of reduced CTh compared with female patients. Disease duration seems more relevant to explain reduced CTh in male patients, suggesting worse prognostic over time. Further studies should explore sex-specific cortical atrophy trajectories using large longitudinal multi-site dataÍtem Parameters from site classification to harmonize MRI clinical studies: application to a multi-site Parkinson's disease dataset(John Wiley & Sons, Inc, 2022-03-19) Monté Rubio, Gemma Cristina; Segura, Barbara; Strafella, Antonio P.; Eimeren, Thilo van; Ibarretxe Bilbao, Naroa; Díez Cirarda, María ; Eggers, Carsten ; Lucas Jiménez, Olaia; Ojeda del Pozo, Natalia; Peña Lasa, Javier; Ruppert, Marina C. ; Sala Llonch, Roser ; Theis, Hendrik; Uribe, Carme; Junqué i Plaja, CarmeMulti-site MRI datasets are crucial for big data research. However, neuroimaging studies must face the batch effect. Here, we propose an approach that uses the predictive probabilities provided by Gaussian processes (GPs) to harmonize clinical-based studies. A multi-site dataset of 216 Parkinson's disease (PD) patients and 87 healthy subjects (HS) was used. We performed a site GP classification using MRI data. The outcomes estimated from this classification, redefined like Weighted HARMonization PArameters (WHARMPA), were used as regressors in two different clinical studies: A PD versus HS machine learning classification using GP, and a VBM comparison (FWE-p <.05, k = 100). Same studies were also conducted using conventional Boolean site covariates, and without information about site belonging. The results from site GP classification provided high scores, balanced accuracy (BAC) was 98.39% for grey matter images. PD versus HS classification performed better when the WHARMPA were used to harmonize (BAC = 78.60%; AUC = 0.90) than when using the Boolean site information (BAC = 56.31%; AUC = 0.71) and without it (BAC = 57.22%; AUC = 0.73). The VBM analysis harmonized using WHARMPA provided larger and more statistically robust clusters in regions previously reported in PD than when the Boolean site covariates or no corrections were added to the model. In conclusion, WHARMPA might encode global site-effects quantitatively and allow the harmonization of data. This method is user-friendly and provides a powerful solution, without complex implementations, to clean the analyses by removing variability associated with the differences between sites.Ítem Predictors of health-related quality of life in Parkinson’s disease: the impact of overlap between health-related quality of life and clinical measures(Springer Nature, 2022-07-16) Sanchez Luengos, Itsasne; Lucas Jiménez, Olaia; Ojeda del Pozo, Natalia; Peña Lasa, Javier ; Gómez Esteban, Juan Carlos ; Gómez Beldarrain, María Ángeles ; Vázquez Picón, Raquel; Foncea Beti, Nerea; Ibarretxe Bilbao, NaroaThis study aimed to determine predictors of health-related quality of life (HRQoL) in Parkinson's disease (PD) and to explore their predictive value before and after controlling overlapping items between HRQoL and clinical variables. One hundred and eight PD patients underwent motor, anxiety, depression, apathy, fatigue, and neurocognition assessment. HRQoL was assessed by the Parkinson’s Disease Questionnaire-39 (PDQ-39). In order to determine predictors of HRQoL in PD, stepwise multiple regression analyses were performed in two ways: before and after removing the emotional well-being dimension from PDQ-39 to control the overlap between depression and anxiety, and HRQoL. HRQoL total index was predicted by anxiety, fatigue, motor symptoms, and depression, explaining 26.9%, 7.2%, 2.8%, and 1.9% of the variance. However, after removing overlapping items, HRQoL total index was predicted by fatigue (16.5%), anxiety (6.1%), motor symptoms (3.9%), and neurocognition (2.5%), but not depression. Regarding HRQoL dimensions, mobility and activities of daily living were predicted by fatigue (19.7% and 5%) and UPDRS-III (4% and 10.2%); emotional well-being by fatigue (7.9%); social support by anxiety (12.2%) and UPDRS-III (8.6%); communication by neurocognition (5.3%) and UPDRS-III (3.4%); cognition by anxiety (10.6%) and bodily discomfort by anxiety (23%) and fatigue (4.1%). These findings showed the importance of identifying and controlling overlapping items of HRQoL and clinical measures to perform an accurate interpretation. HRQoL dimensions showed different predictors before and after controlling the overlap. Based on these results fatigue, anxiety, motor symptoms, and neurocognition, but not depression are the main predictors of HRQoL in PD patients.Ítem Preterm birth and early life environmental factors: neuropsychological profiles at adolescence and young adulthood(Springer Nature, 2023-11) Fernández de Gamarra Oca, Lexuri; Zubiaurre Elorza, Leire; Gómez-Gastiasoro, Ainara; Molins Sauri, Marta; Loureiro González, Begoña; Peña Lasa, Javier; García Guerrero, Acebo; Ibarretxe Bilbao, Naroa; Bruna i Rabassa, Olga; Junqué i Plaja, Carme; Macaya Ruiz, Alfons; Poca Pastor, Maria Antònia; Ojeda del Pozo, NataliaObjectives: To establish neuropsychological profiles after high- and low-risk preterm birth (i.e., with and without neonatal brain injury) during adolescence and young adulthood and to assess the potential role of early life environmental factors in cognition. Study design: Participants (N = 177; Mage = 20.11 years) of both sexes were evaluated when adolescent or in young adulthood. They were grouped according to their birth status: 30 high-risk preterm, 83 low-risk preterm and 64 born at full term. Results: Significant differences were found in several cognitive domains between groups. Furthermore, familial socioeconomic status (SES) moderated the relation between the degree of maturity/immaturity at birth and cognition (F (5,171) = 11.94, p < 0.001, R 2 = 0.26). Discussion: The findings showed different neuropsychological profiles during adolescence and young adulthood, with the high-risk preterm sample evidencing lower cognitive values. In addition, higher scores in the familial SES score in this study seem to have a protective effect on cognition.Ítem Reliable change indices for 16 neuropsychological tests at six different time points(Spanish Society of Neurology, 2025-04) Sáez Atxukarro, Oihane; Peña Lasa, Javier; Pino, Rocío del; Ibarretxe Bilbao, Naroa; Ojeda del Pozo, NataliaIntroduction: Neuropsychological assessment often involves repeated testing in order to assess a cognitive change or conduct a longitudinal follow-up study of a patient. To assess whether the change between assessments is relevant or not, longitudinal reference data are needed. The aim of this study is to provide reference data to enable interpretation of score changes between assessments for 16 commonly used tests, at six different time intervals between successive assessments, using five reliable change indices. Methods: The study is part of the Normacog project, in which 388 healthy participants recruited in Spain (aged 18–84 years) were assessed on two occasions. A baseline assessment was carried out, and then followed up at 1 month (n = 67), 3 months (n = 64), 6 months (n = 59), 9 months (n = 60), 12 months (n = 68), or 24 months (n = 70). Longitudinal data were analyzed, and reliable change indices were calculated. Results: A significant improvement was observed between assessment scores for all time points, especially in memory-related variables. Reference data are provided using the following indices: discrepancy scores expressed in percentiles, standard deviation index (SDI), reliable change index (RCI), RCI + practice effect (RCI + PE), and standardized regression-based formulae. Conclusions: This study provides data to analyze whether or not a cognitive change can be considered reliable. The results support the use of these reliable change indices to avoid biases related to successive assessments. This study will lay the foundations for the implementation of these tools in clinical practice, and will be a reference for the creation of reliable change indicesÍtem Retinal thickness predicts the risk of cognitive decline in Parkinson disease(John Wiley and Sons Inc, 2021-01) Murueta-Goyena Larrañaga, Ane ; Pino, Rocío del; Galdos Iztueta, Marta; Arana Larrea, Begoña; Acera Gil, María Ángeles ; Carmona Abellán, Mar; Fernández Valle, Tamara ; Tijero Merino, Beatriz ; Lucas Jiménez, Olaia; Ojeda del Pozo, Natalia ; Ibarretxe Bilbao, Naroa ; Peña Lasa, Javier; Cortés, Jesús; Ayala Fernández, Unai; Barrenechea Carrasco, Maitane; Gómez Esteban, Juan Carlos ; Gabilondo Cuellar, IñigoObjective: This study was undertaken to analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD). Methods: Patients with Lewy body diseases were enrolled and prospectively evaluated at 3 years, including patients with iPD (n = 42), dementia with Lewy bodies (n = 4), E46K-SNCA mutation carriers (n = 4), and controls (n = 17). All participants underwent Spectralis retinal optical coherence tomography and Montreal Cognitive Assessment, and Unified Parkinson's Disease Rating Scale score was obtained in patients. Macular ganglion cell–inner plexiform layer complex (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness reduction rates were estimated with linear mixed models. Risk ratios were calculated to evaluate the association between baseline GCIPL and pRNFL thicknesses and the risk of subsequent cognitive and motor worsening, using clinically meaningful cutoffs. Results: GCIPL thickness in the parafoveal region (1- to 3-mm ring) presented the largest reduction rate. The annualized atrophy rate was 0.63μm in iPD patients and 0.23μm in controls (p < 0.0001). iPD patients with lower parafoveal GCIPL and pRNFL thickness at baseline presented an increased risk of cognitive decline at 3 years (relative risk [RR] = 3.49, 95% confidence interval [CI] = 1.10–11.1, p = 0.03 and RR = 3.28, 95% CI = 1.03–10.45, p = 0.045, respectively). We did not identify significant associations between retinal thickness and motor deterioration. Interpretation: Our results provide evidence of the potential use of optical coherence tomography–measured parafoveal GCIPL thickness to monitor neurodegeneration and to predict the risk of cognitive worsening over time in iPDÍtem Test UD Interferencia: creación y validación de un nuevo instrumento de resistencia a la interferencia: normalización y estandarización en población española(Spanish Society of Neurology, 2023-10) Sáez Atxukarro, Oihane; Pino, Rocío del; Peña Lasa, Javier; Schretlen, David J.; Ibarretxe Bilbao, Naroa; Ojeda del Pozo, NataliaIntroducción: El test UD Interferencia evalúa la velocidad de procesamiento y la atención, y está basado en el concepto de interferencia del test de Stroop. El objetivo principal de este estudio es proporcionar una versión alternativa del test de Stroop que evite algunas de las limitaciones de versiones anteriores, relacionadas con el daltonismo y las dificultades de lectura en personas mayores, y obtener datos normativos y estandarizados para este test, adaptados a población española. Métodos: El estudio se enmarca dentro del proyecto Normacog, para el cual se evaluó a 905 participantes (18-93 años). Se analizó la fiabilidad y la validez concurrente y de constructo del test. Se analizaron el efecto de la edad, nivel educativo y sexo sobre el rendimiento en UD Interferencia y se crearon percentiles y puntuaciones escalares ajustadas por edad y nivel educativo. Resultados: El test muestra buena fiabilidad ( = 0,875) y validez concurrente (r de 0,443 a 0,725; p < 0,001) y de constructo (r de 0,472 a 0,737; p < 0,001). Se observó un efecto significativo de la edad y el nivel educativo sobre el rendimiento en UD Interferencia, explicando del 12 al 40% de la varianza. El sexo únicamente presentó un efecto significativo en la variable índice de resistencia a la interferencia. Conclusiones: Se presenta una versión alternativa del test de Stroop que presenta algunas ventajas sobre anteriores versiones. Se aportan baremos estandarizados y normalizados para población española que permiten corregir el test teniendo en cuenta la edad y educación de la persona evaluada