Examinando por Autor "Lersundi Artamendi, Ana"

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  • Miniatura
    Ítem
    Manual therapy and neck-specific exercise are equally effective for treating non-specific neck pain but only when exercise adherence is maximised: a randomised controlled trial
    (Elsevier Ltd, 2025-03-21) Villanueva Ruiz, Iker; Falla, Deborah; Saez, Marc; Araolaza Arrieta, Maialen; Azkue Barrenetxea, Jon Jatsu; Arbillaga Etxarri, Ane; Lersundi Artamendi, Ana; Lascurain-Aguirrebeña, Ion
    Objective: To assess the effectiveness of manual therapy versus a progressive, tailored neck-specific exercise program with high adherence for treating non-specific chronic neck pain (NSNP) and to examine the relationship between exercise adherence and treatment outcome. Design: Single-blind, parallel, randomized clinical trial with two treatment arms, adhering to CONSORT guidelines. Methods: 65 NSNP participants were randomly allocated to manual therapy or exercise. They received four treatment sessions of either manual therapy or neck-specific exercise, once a week for four weeks. Outcomes measured at baseline, two weeks, four weeks, and 12 weeks post-treatment included pain intensity, disability, patient-perceived improvement, quality of life, kinesiophobia and the craniocervical flexion test (CCFT) performance. In addition to evaluating each individual outcome, patients were categorized into either responders or non-responders according to pain intensity, disability and patient-perceived improvement. Exercise adherence was recorded. Results: There were no differences between groups in individual outcomes. Treatment outcome in the exercise group was associated with exercise adherence. Patients receiving manual therapy were more likely to be classified as responders than those receiving exercise at all measured time points (odds ratio, 2 weeks: 0.14; 95 % CI: 0.02–0.79; treatment completion: 0.31; 95 % CI: 0.12–0.82; 12 weeks after treatment completion: 0.19; 95 % CI: 0.05–0.65), however these differences were no longer present when only patients whose exercise adherence was ≥95 % were analysed. Exercise was more effective than manual therapy in improving CCFT performance but only if patients with ≥95 % adherence were considered. Conclusion: A four-week intervention of manual therapy was more effective than exercise, however when exercise adherence was ≥95 %, the interventions were equally effective. Manual therapy may only be superior to specific-exercise when high exercise adherence cannot be assured.
  • Miniatura
    Ítem
    The role of integrin β1D mislocalization in the pathophysiology of calpain 3-related limb–girdle muscular dystrophy
    (Multidisciplinary Digital Publishing Institute (MDPI), 2025-03) Valls Rodríguez, Andrea; Ruiz Roldán, Cristina; Immanuel, Jenita; Alonso-Martin, Sonia; Gallardo, Eduard; Fernández Torrón, Roberto; Bonilla Zagala, Mario; Lersundi Artamendi, Ana; Hernández Laín, A.; Domínguez González, Cristina; Vílchez, Juan J.; Iruzubieta Agudo, Pablo; López de Munain Arregui, Adolfo; Sáenz, Amets
    Limb–girdle muscular dystrophy R1 (LGMDR1) is characterized by progressive proximal muscle weakness due to mutations in the CAPN3 gene. Little is known about CAPN3’s function in muscle, but its loss results in aberrant sarcomere formation. Human muscle structure was analyzed in this study, with observations including integrin β1D isoform (ITGβ1D) mislocalization, a lack of Talin-1 (TLN1) in the sarcolemma and the irregular expression of focal adhesion kinase (FAK) in LGMDR1 muscles, suggesting a lack of integrin activation with an altered sarcolemma, extracellular matrix (ECM) assembly and signaling pathway deregulation, which may cause frailty in LGMDR1 muscle fibers. Additionally, altered nuclear morphology, centrosome distribution and microtubule organization have been found in muscle cells derived from LGMDR1 patients