Examinando por Autor "Iriarte Yoller, Nagore"

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  • Miniatura
    Ítem
    Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial
    (Nature Research, 2021-12) Sampedro, Agurne; Peña Lasa, Javier; Sánchez Gómez, Pedro Manuel; Ibarretxe Bilbao, Naroa; Gómez Gastiasoro, Ainara; Iriarte Yoller, Nagore; Pavón, Cristóbal; Tous Espelosín, Mikel; Ojeda del Pozo, Natalia
    This study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in functional outcomes were explored. The program combined cognitive remediation with social cognitive training and social and functional skill training over 20 weeks. The sample included 94 patients, 47 in the REHACOP group and 47 in the active control group (occupational activities). Significant differences were found between the two groups in change scores of processing speed, working memory, verbal memory (VM), inhibition, theory of mind, emotion processing (EP), figural creative strengths, functional competence, disorganization, excitement, and primary negative symptoms. A mediational analysis revealed that changes in VM, inhibition, and EP partially explained the effect of cognitive remediation on functional competence improvement. This study provides initial evidence of the effect of integrative cognitive remediation on primary negative symptoms and creativity.
  • Miniatura
    Ítem
    Moderators of functional improvement after integrative cognitive remediation in schizophrenia: toward a personalized treatment approach
    (Elsevier Ireland Ltd, 2023-11) Sampedro, Agurne; Peña Lasa, Javier; Sánchez Gómez, Pedro Manuel; Ibarretxe Bilbao, Naroa; Iriarte Yoller, Nagore; Pavón, Cristóbal; Ojeda del Pozo, Natalia
    Cognitive remediation is an effective intervention for improving functional outcome in schizophrenia. However, the factors that moderate this improvement are still poorly understood. The study aimed to identify moderators of functional outcome improvement after integrative cognitive remediation (REHACOP) in schizophrenia. This was a secondary analysis of data from two randomized controlled trials, which included 182 patients (REHACOP group=94; active control group=88). Hierarchical regression analyses were conducted to identify moderators of functional outcome improvement. Two baseline level groups (low-level and high-level) were created to analyze the moderating role of this baseline level cluster using repeated measures ANCOVA. The REHACOP was effective regardless of participants’ baseline level, but regression analyses indicated that the effectiveness on functional outcome was higher among those who were older, had fewer years in education, lower scores in baseline cognition and functional outcome, and more negative symptoms. Repeated measures ANOVA showed that the baseline level cluster influenced the improvement in functional outcome, with the low-level group showing greater improvements. The results reinforced the need to implement cognitive remediation programs more broadly as a treatment for schizophrenia in healthcare services. Furthermore, they provided evidence for the development of personalized cognitive remediation plans to improve benefits in different schizophrenia profiles.