Examinando por Autor "Iriarte Yoller, Nagore"

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    Ítem
    Analyzing structural and functional brain changes related to an integrative cognitive remediation program for schizophrenia: a randomized controlled trial
    (Elsevier B.V., 2023-05) Sampedro, Agurne; Ibarretxe Bilbao, Naroa ; Peña Lasa, Javier ; Cabrera Zubizarreta, Alberto; Sánchez Gómez, Pedro Manuel ; Gómez Gastiasoro, Ainara; Iriarte Yoller, Nagore ; Pavón, Cristóbal ; Tous Espelosín, Mikel ; Ojeda del Pozo, Natalia
    Cognitive remediation has been shown to improve cognition in schizophrenia, but little is known about the specific functional and structural brain changes related to the implementation of an integrative cognitive remediation program. This study analyzed the functional and structural brain changes identified after implementing an integrative cognitive remediation program, REHACOP, in schizophrenia. The program combined cognitive remediation, social cognitive training, and functional and social skills training. The sample included 59 patients that were assigned to either the REHACOP group or an active control group for 20 weeks. In addition to a clinical and neuropsychological assessment, T1-weighted, diffusion-weighted and functional magnetic resonance images were acquired during a resting-state and during a memory paradigm, both at baseline and follow-up. Voxel-based morphometry, tract-based spatial statistics, resting-state functional connectivity, and brain activation analyses during the memory paradigm were performed. Brain changes were assessed with a 2 × 2 repeated-measure analysis of covariance for group x time interaction. Intragroup paired t-tests were also carried out. Repeated-measure analyses revealed improvements in cognition and functional outcome, but no significant brain changes associated with the integrative cognitive remediation program. Intragroup analyses showed greater gray matter volume and cortical thickness in right temporal regions at post-treatment in the REHACOP group. The absence of significant brain-level results associated with cognitive remediation may be partly due to the small sample size, which limited the statistical power of the study. Therefore, further research is needed to clarify whether the temporal lobe may be a key area involved in cognitive improvements following cognitive remediation.
  • Miniatura
    Ítem
    Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial
    (Nature Research, 2021-12) Sampedro, Agurne; Peña Lasa, Javier; Sánchez Gómez, Pedro Manuel; Ibarretxe Bilbao, Naroa; Gómez Gastiasoro, Ainara; Iriarte Yoller, Nagore; Pavón, Cristóbal; Tous Espelosín, Mikel; Ojeda del Pozo, Natalia
    This study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in functional outcomes were explored. The program combined cognitive remediation with social cognitive training and social and functional skill training over 20 weeks. The sample included 94 patients, 47 in the REHACOP group and 47 in the active control group (occupational activities). Significant differences were found between the two groups in change scores of processing speed, working memory, verbal memory (VM), inhibition, theory of mind, emotion processing (EP), figural creative strengths, functional competence, disorganization, excitement, and primary negative symptoms. A mediational analysis revealed that changes in VM, inhibition, and EP partially explained the effect of cognitive remediation on functional competence improvement. This study provides initial evidence of the effect of integrative cognitive remediation on primary negative symptoms and creativity.
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    Cross-validation of predictive equation for cardiorespiratory fitness by modified shuttle walk test in adults with schizophrenia: a secondary analysis of the cortex-sp study
    (MDPI, 2021-10-29) Tous Espelosín, Mikel; Ruiz de Azúa García, Sonia; Iriarte Yoller, Nagore; Sánchez Gómez, Pedro Manuel; Elizagarate Zabala, Edorta; Sampedro, Agurne; Maldonado-Martín, Sara
    Cardiorespiratory fitness (CRF) can be direct or estimated from different field tests. The Modified Shuttle Walk Test (MSWT) is suitable for all levels of function, allowing a peak response to be elicited. Therefore, we aimed (1) to validate the equation presented in the original study by Singh et al. for evaluating the relationship between MSWT with peak oxygen uptake (VO2peak) in adults with schizophrenia (SZ), (2) to develop a new equation for the MSWT to predict VO2peak, and (3) to validate the new equation. Participants (N = 144, 41.3 ± 10.2 years old) with SZ performed a direct measurement of VO2peak through a cardiopulmonary exercise test and the MSWT. A new equation incorporating resting heart rate, body mass index, and distance from MSWT (R2 = 0.617; adjusted R2 = 0.60; p < 0.001) performs better than the Singh et al. equation (R2 = 0.57; adjusted R2 = 0.57; p < 0.001) to estimate VO2peak for the studied population. The posteriori cross-validation method confirmed the model’s stability (R2 = 0.617 vs. 0.626). The findings of the current study support the validity of the new regression equation incorporating resting heart rate, body mass index, and distance from MSWT to predict VO2peak for assessment of CRF in people with SZ.
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    The impact of creativity on functional outcome in schizophrenia: a mediational model
    (Nature Research, 2021-02-26) Sampedro, Agurne ; Peña Lasa, Javier; Sánchez Gómez, Pedro Manuel; Ibarretxe Bilbao, Naroa; Iriarte Yoller, Nagore; Pavón, Cristóbal; Hervella Garcés, Isabel; Tous Espelosín, Mikel; Ojeda del Pozo, Natalia
    Functional impairment remains one of the most challenging issues for treatment in schizophrenia. However, previous studies have mainly focused on the negative impact of symptoms excluding variables that could positively impact functional outcome, such as creativity, which is considered an adaptive capacity for real-life problem-solving. This study analyzed the predictive role of creativity on functional outcome in 96 patients with schizophrenia through a mediational model, including sociodemographic, clinical, neurocognitive, and social cognitive variables. Path analysis revealed that creativity significantly mediated the relationship between neurocognition and functional outcome, and that creativity mediated between negative symptoms and functional outcome. Additionally, neurocognition was directly associated with functional outcome and social functioning was associated with creativity. The involvement of creativity in functional outcome could have relevant implications for the development of new interventions. These findings open up a new field of research on additional personal resources as possible factors of functional outcome in schizophrenia and other diseases
  • Miniatura
    Ítem
    Moderators of functional improvement after integrative cognitive remediation in schizophrenia: toward a personalized treatment approach
    (Elsevier Ireland Ltd, 2023-11) Sampedro, Agurne; Peña Lasa, Javier; Sánchez Gómez, Pedro Manuel; Ibarretxe Bilbao, Naroa; Iriarte Yoller, Nagore; Pavón, Cristóbal; Ojeda del Pozo, Natalia
    Cognitive remediation is an effective intervention for improving functional outcome in schizophrenia. However, the factors that moderate this improvement are still poorly understood. The study aimed to identify moderators of functional outcome improvement after integrative cognitive remediation (REHACOP) in schizophrenia. This was a secondary analysis of data from two randomized controlled trials, which included 182 patients (REHACOP group=94; active control group=88). Hierarchical regression analyses were conducted to identify moderators of functional outcome improvement. Two baseline level groups (low-level and high-level) were created to analyze the moderating role of this baseline level cluster using repeated measures ANCOVA. The REHACOP was effective regardless of participants’ baseline level, but regression analyses indicated that the effectiveness on functional outcome was higher among those who were older, had fewer years in education, lower scores in baseline cognition and functional outcome, and more negative symptoms. Repeated measures ANOVA showed that the baseline level cluster influenced the improvement in functional outcome, with the low-level group showing greater improvements. The results reinforced the need to implement cognitive remediation programs more broadly as a treatment for schizophrenia in healthcare services. Furthermore, they provided evidence for the development of personalized cognitive remediation plans to improve benefits in different schizophrenia profiles.