Examinando por Autor "Catalli, Claudio"

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    Neuropsychological profile of hereditary ataxias: study of 38 patients
    (Oxford University Press, 2022-08) García Martín, Maitane; Rouco Axpe, Idoia; Amayra Caro, Imanol; Rodríguez-Antigüedad Zarranz, Alfredo; Catalli, Claudio; Cabrera Zubizarreta, Alberto; Rodríguez Bermejo, Alicia Aurora; Pérez Álvarez, Manuel
    Hereditary ataxias are a heterogeneous group of disorders characterized by degeneration of the cerebellum and its connections. It is known that patients with ataxia can manifest a broad spectrum of motor symptoms; however, current research has emphasized the relevance of cognitive disturbances. The aim of this study is to analyze the presence of cognitive impairment in a heterogeneous cohort of patients with hereditary ataxia (HA). A group of 38 patients with HA of different etiologies and a matched group of 38 healthy controls were recruited and evaluated through a comprehensive battery of neuropsychological tests. The findings show a worse performance in ataxic patients on planning, visuospatial skills, naming, and Theory of Mind tasks, regardless their physical and psychological symptomatology. The influence of clinical status as well as functional ability-related variables on their performance were analyzed, showing that the level of disability and motor disturbances have a significant effect on verbal memory, verbal fluency, and working memory. These findings suggest that patients with HA can manifest cognitive and neuropsychiatric symptoms as part of their clinical features, which demands its inclusion for the diagnosis and management of the disease