Examinando por Autor "Cabrera Zubizarreta, Alberto"

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    Analyzing structural and functional brain changes related to an integrative cognitive remediation program for schizophrenia: a randomized controlled trial
    (Elsevier B.V., 2023-05) Sampedro, Agurne; Ibarretxe Bilbao, Naroa ; Peña Lasa, Javier ; Cabrera Zubizarreta, Alberto; Sánchez Gómez, Pedro Manuel ; Gómez Gastiasoro, Ainara; Iriarte Yoller, Nagore ; Pavón, Cristóbal ; Tous Espelosín, Mikel ; Ojeda del Pozo, Natalia
    Cognitive remediation has been shown to improve cognition in schizophrenia, but little is known about the specific functional and structural brain changes related to the implementation of an integrative cognitive remediation program. This study analyzed the functional and structural brain changes identified after implementing an integrative cognitive remediation program, REHACOP, in schizophrenia. The program combined cognitive remediation, social cognitive training, and functional and social skills training. The sample included 59 patients that were assigned to either the REHACOP group or an active control group for 20 weeks. In addition to a clinical and neuropsychological assessment, T1-weighted, diffusion-weighted and functional magnetic resonance images were acquired during a resting-state and during a memory paradigm, both at baseline and follow-up. Voxel-based morphometry, tract-based spatial statistics, resting-state functional connectivity, and brain activation analyses during the memory paradigm were performed. Brain changes were assessed with a 2 × 2 repeated-measure analysis of covariance for group x time interaction. Intragroup paired t-tests were also carried out. Repeated-measure analyses revealed improvements in cognition and functional outcome, but no significant brain changes associated with the integrative cognitive remediation program. Intragroup analyses showed greater gray matter volume and cortical thickness in right temporal regions at post-treatment in the REHACOP group. The absence of significant brain-level results associated with cognitive remediation may be partly due to the small sample size, which limited the statistical power of the study. Therefore, further research is needed to clarify whether the temporal lobe may be a key area involved in cognitive improvements following cognitive remediation.
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    Neuropsychological profile of hereditary ataxias: study of 38 patients
    (Oxford University Press, 2022-08) García Martín, Maitane; Rouco Axpe, Idoia; Amayra Caro, Imanol; Rodríguez-Antigüedad Zarranz, Alfredo; Catalli, Claudio; Cabrera Zubizarreta, Alberto; Rodríguez Bermejo, Alicia Aurora; Pérez Álvarez, Manuel
    Hereditary ataxias are a heterogeneous group of disorders characterized by degeneration of the cerebellum and its connections. It is known that patients with ataxia can manifest a broad spectrum of motor symptoms; however, current research has emphasized the relevance of cognitive disturbances. The aim of this study is to analyze the presence of cognitive impairment in a heterogeneous cohort of patients with hereditary ataxia (HA). A group of 38 patients with HA of different etiologies and a matched group of 38 healthy controls were recruited and evaluated through a comprehensive battery of neuropsychological tests. The findings show a worse performance in ataxic patients on planning, visuospatial skills, naming, and Theory of Mind tasks, regardless their physical and psychological symptomatology. The influence of clinical status as well as functional ability-related variables on their performance were analyzed, showing that the level of disability and motor disturbances have a significant effect on verbal memory, verbal fluency, and working memory. These findings suggest that patients with HA can manifest cognitive and neuropsychiatric symptoms as part of their clinical features, which demands its inclusion for the diagnosis and management of the disease