Examinando por Autor "Aguirre Larracoechea, Urko"

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    Development and application of a multi-objective tool for thermal design of heat exchangers using neural networks
    (MDPI AG, 2021-05) Andrés Honrubia, José Luís de; Gaviria de la Puerta, José; Cortés Martínez, Fernando; Aguirre Larracoechea, Urko; Goti Elordi, Aitor; Retolaza, Jone
    This paper presents the design of a multi-objective tool for sizing shell and tube heat exchangers (STHX), developed under a University/Industry collaboration. This work aims to show the feasibility of implementing artificial intelligence tools during the design of Heat Exchangers in industry. The design of STHX optimisation tools using artificial intelligence algorithms is a visited topic in the literature, nevertheless, the degree of implementation of this concept is uncommon in industrial companies. Thus, the challenge of this research consists of the development of a tool for the design of STHX using artificial intelligence algorithms that can be used by industrial companies. The approach is implemented using a simulated dataset contrasted with ARA TT, the company taking part in the project. The given dataset to develop a theoretical STHX calculator was modeled using MATLAB. This dataset was used to train seven neural networks (NNs). Three of them were mono-objective, one per objective to predict, and four were multi-objective. The last multi-objective NN was used to develop an inverse neural network (INN), which is used to find the optimal configuration of the STHXs. In this specific case, three design parameters, the pressure drop on the shell side, the pressure drop on the tube side and heat transfer rate, were jointly and successfully optimised. As a conclusion, this work proves that the developed tool is valid in both terms of effectiveness and user-friendliness for companies like ARA TT to improve their business activity.
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    Problematic gambling behavior in a sample with substance use disorder: the role of attachment style and alexithymia
    (Springer, 2023-06) Rueda Ruiz, Begoña; Aguirre Larracoechea, Urko; Herrero Lázaro, Marta; Estévez Gutiérrez, Ana
    Gambling disorder is a high comorbid disorder in substance abusers which conjunct appearance is related to worse symptomatology and evolution. Nevertheless, the research on the risk factors that may explain this comorbidity is scarce. We build of the self-regulation theory of attachment and addiction to examine if insecure attachment is related to gambling comorbidity in substance abuse disorder and the mediating role of alexithymia in this process. A cross-sectional study was carried out with 369 clinical patients with substance use disorder of which 69 presented comorbid gambling disorder diagnosed with the DSM-5 criteria. Results showed that insecure attachment was more prevalent in the group with comorbid gambling. In this group, the alexithymia levels were also higher and mediated the relationship in between attachment and gambling disorder comorbidity even controlling for several sociodemographic variables. This research indicates that insecure attachment enhances the risk of gambling comorbidity on substance abusers due to the detrimental effect on the self-regulation of emotion. Thus, interventions directed to increase the identification, expression and awareness of emotions might help to reduce comorbidity of gambling of substance use disorders.
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    Subclinical bowel inflammation increases healthcare resources utilization and steroid use before diagnosis of inflammatory bowel disease
    (John Wiley and Sons Inc, 2023-02) Rodríguez Lago, Iago; Aguirre Larracoechea, Urko ; Ramírez de la Piscina, Patricia; Muñagorri, Ana I.; Zapata, Eva ; Higuera, Rebeca; Montalvo, Isabel; Iriarte, Ainara; Fernández Calderón, María; Arreba González, Paz; Carrascosa, Juan; Cabriada, José Luis ; Barreiro de Acosta, Manuel
    Background: Previous data support that the inflammatory process underlying ulcerative colitis (UC) and Crohn's disease (CD) can start years before the diagnosis. The aim of this study was to determine if patients with an incidental diagnosis of UC or CD demonstrate an increase in healthcare utilization in the years preceding the symptomatic onset of the disease. Methods: We performed a multicenter, retrospective, hospital-based, case-control study. Patients with an incidental diagnosis of UC or CD during the colorectal cancer screening program at 9 hospitals were included. Cases were matched 1:3 and compared separately with two control populations: one including healthy non-IBD subjects adjusted by gender, age, and date, excluding those with visits to Gastroenterology; and a second control cohort of UC/CD patients with symptomatic onset. Results: A total of 124 patients with preclinical inflammatory bowel disease (IBD) were included (87 UC, 30 CD, 7 IBD unclassified; median age 56 years). Patients with preclinical IBD showed an increase in the number of visits to Primary Care up to 3 and 5 years before diagnosis (aIRR 1.59, 95% CI [1.37–1.86], p = 0.001; aIRR 1.43, 95% CI [1.24–1.67], p = 0.01) and more frequent use of steroids (aOR 2.84, 95% CI [1.21–6.69], p = 0.03; aOR 2.25, 95% CI [1.06–4.79], p = 0.04) compared to matched non-IBD healthy controls, respectively. In contrast, patients with a symptomatic onset visited Primary Care less frequently, but they had an increase in the number of visits to Emergency Department, specialist care, sick-leaves, CT/ultrasound examinations, and use of antibiotics or systemic steroids. Conclusions: There is an increased need for medical assistance and use of systemic steroids during the presymptomatic phase of IBD. These results will help in establishing new tools for early identification of IBD in the future.