Repositorio Institucional
El repositorio institucional recoge la producción científica del personal docente e investigador de la Universidad de Deusto. Su propósito es reunir, archivar, preservar y aumentar la visibilidad en acceso abierto de los resultados de investigación.
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The role of integrin β1D mislocalization in the pathophysiology of calpain 3-related limb–girdle muscular dystrophy
(Multidisciplinary Digital Publishing Institute (MDPI), 2025-03) Valls Rodríguez, Andrea; Ruiz Roldán, Cristina; Immanuel, Jenita; Alonso-Martin, Sonia; Gallardo, Eduard; Fernández Torrón, Roberto; Bonilla Zagala, Mario; Lersundi Artamendi, Ana; Hernández Laín, A.; Domínguez González, Cristina; Vílchez, Juan J.; Iruzubieta Agudo, Pablo; López de Munain Arregui, Adolfo; Sáenz, Amets
Limb–girdle muscular dystrophy R1 (LGMDR1) is characterized by progressive proximal muscle weakness due to mutations in the CAPN3 gene. Little is known about CAPN3’s function in muscle, but its loss results in aberrant sarcomere formation. Human muscle structure was analyzed in this study, with observations including integrin β1D isoform (ITGβ1D) mislocalization, a lack of Talin-1 (TLN1) in the sarcolemma and the irregular expression of focal adhesion kinase (FAK) in LGMDR1 muscles, suggesting a lack of integrin activation with an altered sarcolemma, extracellular matrix (ECM) assembly and signaling pathway deregulation, which may cause frailty in LGMDR1 muscle fibers. Additionally, altered nuclear morphology, centrosome distribution and microtubule organization have been found in muscle cells derived from LGMDR1 patients
Assessment of the effectiveness of the parenting intervention programme “Intelligent Families”: a randomised controlled study
(Multidisciplinary Digital Publishing Institute (MDPI), 2025-03) Martínez Pampliega, Ana; Ortuño, Antonio; Mónaco Gerónimo, Estefanía
This study presents and analyses the effectiveness of the programme “Intelligent Families” aimed at promoting the development of parenting skills in parents within the framework of positive parenting. The popularity of attachment- and emotion-based interventions seems to have grown among clinicians, researchers and parents. However, in Spain, these programmes are practically non-existent or do not provide evidence of their effectiveness. A randomised experimental study with two groups (experimental and control) and a longitudinal design (pre, post and follow-up) was conducted to test the programme’s impact on parenting skills. The sample comprised 637 Spanish parents. Two moderating variables were considered: the modality (face-to-face or online) and the length of the intervention (2 or 4 sessions). The experimental group significantly increased their empathic authority, established rules with confidence and sensitivity, and could negotiate in everyday family conflicts. There were no differences according to the parent’s gender, the children’s age, or the intervention’s modality or duration. This study verified the effectiveness of the “Intelligent Families” intervention programme. The importance of developing and studying the effectiveness of preventive actions to promote families’ emotional well-being is discussed
How dominant language influences rubric reading and task performance: insights from eye-tracking research
(Springer Science and Business Media B.V., 2025-06) Panadero, Ernesto; Delgado, Pablo; Barrenetxea Mínguez, Lucía; Zamorano Sande, David; Pinedo Castillo, Leire; Fernández Ortube, Alazne
The students’ dominant language might influence how they use and process a rubric and its subsequent effect on task performance. However, our knowledge about these effects is limited. This study investigates how the dominant language of students is associated with their rubric reading patterns and their task performance in a written landscape analysis in Spanish. Participants were 80 higher education students with different dominant language (Spanish-dominant speakers, SDS; Basque-Spanish speakers, BSS) from six undergraduate programmes. We employed a randomized controlled trial in which participants used a rubric to guide their performance in a written analysis of a landscape. Participants were randomly assigned to two conditions based on the rubric order: (1) lowest to highest performance level vs (2) highest to lowest performance level. We analyzed eye-tracking data to explore reading patterns (i.e., fixation times on the rubric cells and gaze transitions between the rubric and the picture of the landscape), task performance (i.e., written landscape analysis), and self-reported cognitive load. Spanish-dominant speakers exhibited more adaptive reading patterns and performed better in the written landscape analysis with the highest-lowest performance level (PL) order rubric, compared to Basque-Spanish speakers. Additionally, fixation time on highest PL and gaze transitions between highest PL and the landscape picture were positively correlated with task performance. Our research highlights the importance of considering dominant language in rubric design and implementation, showing that strategic rubric design can enhance student performance, particularly in linguistically diverse educational settings
Carbon and water footprint of food loss and waste prevention actions: cradle-to-grave life cycle assessment of a prepared salad
(Elsevier Ltd, 2025-04-10) Amador Cervera, Manuel; Scherhaufer, Silvia; Gollnow, Sebastian; Alonso Vicario, Ainhoa
Food loss and waste (FLW) represents a major challenge for sustainable development. FLW prevention actions are proliferating, but key gaps persist in assessing their actual net environmental benefits, particularly in prevention at the point of generation. Additionally, data transparency is still a key issue. This study aims to assess the environmental impacts avoided by 5 groups of FLW prevention actions implemented in a prepared salad case study in Spain. Additionally, 4 different salad recipes are analysed, so that the influence of ingredient composition on the effectiveness of FLW prevention actions is accounted for as well. A cradle-to-grave life cycle assessment (LCA) was conducted to have a holistic view of the real impacts across the entire system. The methodology involves an identification and characterisation of the points of FLW generation, enabling a more precise estimation of the FLW that can be reduced through prevention actions. Results indicate that innovative governance solutions yield the most positive impacts, avoiding climate change impacts by 9.8 and water use by 8.80 %. The salad with higher proportions of animal-based ingredients experienced the largest impact reductions. These findings highlight areas for targeted prevention efforts for decision makers. Primary production generated the most environmental impacts coming from FLW. However, the holistic perspective taken demonstrated that effective prevention should focus on downstream points of generation. In conclusion, the presented LCA approach accurately identifies the most promising FLW prevention opportunities to improve the environmental performance of food products. The enhanced data transparency improves accuracy and promotes openness and accountability in LCA and FLW research
Predictive assessment of eating disorder risk and recovery: uncovering the effectiveness of questionnaires and influencing characteristics
(Elsevier B.V., 2025) Pikatza Huerga, Amaia; Las Hayas Rodríguez, Carlota; Zulaika Zurimendi, Unai; Almeida, Aitor
This study aims to assess the predictive capabilities of various questionnaires in determining the risk of Eating Disorders (ED) and predicting the level of recovery among individuals. Employing machine learning models and diverse datasets, the research focuses on understanding the effectiveness of different questionnaires in providing insights into ED symptoms and recovery outcomes. Additionally, the study seeks to identify the characteristics that significantly influence the recovery process. The investigation aims to contribute valuable information to enhance the diagnostic and monitoring tools used in the field of mental health, particularly concerning ED