Fongang, BernardSargurupremraj, MuralidharanJian, XueqiuMishra, AniketDamotte, VincentRojas, Itziar deSkrobot, OliviaBis, Joshua C.Fan, Kang-HsienJacobsen, ErinLi, Gloria Hoi-YeeYang, JingyunAlessandra, BizzarroAlessandra, LauriaHilal, SaimaChong, Joyce RuifenChai, Yuek LingKnol, M.J.Pina Concas, MariaGiorgia, GirottoRiaz, MoeenYu, ChenglongGuojonsson, AlexanderLacaze, PaulNaj, Adam C.Gireud-Goss, MonicaWadop, Yannick N.Soumare, AichaBouteloup, VincentGudnason, VilmundurBattista, PetronillaSantin, AuroraSpedicati, BeatriceSardone, RodolfoLauner, LenoreBressler, JanGottesman, Rebecca F.Le Grand, QuentinCaro, IlanaRoshchupkin, Gennady V.Leonard, Hampton L.Yang, ChaojieBartz, Traci M.Bordes, ConstanceRidker, Paul M.Geerlings, Mirjam I.Gasca, Natalie C.Manichaikul, AniNalls, Mike A.Rich, Stephen S.Schmidt, Carsten O.Trompet, StellaSetten, Jessica vanVugt, Marion vanGrabe, Hans J.Jukema, J. WouterRissanen, Ina L.Wassertheil-Smoller, SylviaIkram, M. ArfanSimonsick, Eleanor M.Longstreth, W.T.Chasman, Daniel I.Rotter, Jerome I.Sattar, NaveedStott, David J.Shiroma, Eric J.Sigurdsson, SigurdurGhanbari, MohsenSchminke, UlfBoerwinkle, EricAparicio, Hugo J.Beiser, Alexa S.Romero, José R.Lioutas, VasileiosWang, RuiqiSarnowski, ChloeTeumer, AlexanderVölker, UweMosley, Thomas H.Marquié, MartaGarcía González, PabloOlivé, ClàudiaPuerta, RaquelCano, AmandaSotolongo Grau, ÓscarValero, SergiPytel, Vanesa VerónicaRosende-Roca, MaitéeAlegret, MontserratTàrraga, LluísBoada, MercèCarracedo, ÁngelFranco Macías, EmilioPiñol Ripoll, GerardGarcía Ribas, GuillermoPérez Tur, JordiRoyo, Jose LuísGarcía Alberca, Jose MaríaReal, Luis MiguelSáez, María EugeniaBullido, María J.Calero, MiguelMedina, MiguelMir, PabloSánchez Juan, PascualPastor, PauÁlvarez, VictoriaGrenier-Boley, BenjaminKüçükali, FahriVan der Lee, SvenPeters, OliverSchneider, AnjaDichgans, MartinRujescu, DanDeckert, JürgenDüzel, EmrahWiltfang, JensWagner, MichaelGrimmer, TimoScarmeas, NikolaosMoreno, FermínSánchez Valle, RaquelReal, Luis M.Rodríguez Rodríguez, EloyLópez de Munain Arregui, AdolfoMendonça, Alexandre deHort, JakubGraff, CarolinePapenberg, GoranGiedraitis, VilmantasNordestgaard, Børge G.Soininen, HilkkaKivipelto, MiiaHaapasalo, AnnakaisaNicolás, GaelPasquier, FlorenceHanon, OlivierGrünblatt, EdnaGalimberti, DanielaArosio, BeatriceMecocci, PatriziaSquassina, AlessioTremolizzo, LucioRainero, InnocenzoSeripa, DavideWilliams, JulieAmouyel, PhilippeJessen, FrankMagda, TsolakiFrikke-Schmidt, RuthSleegers, KristelEngelborghs, SebastiaanVandenberghe, RikIngelsson, MartinRossi, GiacominaHiltunen, MikkoSims, RebeccaGugała-Iwaniuk, MagdalenaLai, Mitchell K. P.Venketasubramanian, N.Tan, Boon-YeowCefalù, Angelo BaldassareArmstrong, Nicola J.Baschi, RobertaBordet, RegisBordet, Anne-MarieBrodaty, HenryDjurovic, SrdjanD'Onofrio, GraziaEsiri, MargaretGelé, PatrickJuárez Cedillo, TeresaKalaria, RajKarhunen, PekkaLaczo, JanLerch, OndrejMasullo, CarloMather, Karen A.Matoska, VaclavMelkas, SusannaMonastero, RobertoNumbers, KatyaPanza, FrancescoPolvikoski, Tuomo M.Quinn, JoeRongve, ArvidSachdev, Perminder S.Scamosci, MichelaThalamuthu, AnbupalamTybjærg-Hansen, AnneVyhnalek, MartinWestaway, Shawn K.Martinsen, Amy E.Skogholt, Anne HeidiWiller, Cristen J.Stordal, EysteinBråthen, GeirNielsen, Jonas BilleFritsche, Lars G.Thomas, Laurent F.Pedersen, Linda M.Gabrielsen, Maiken E.Drange, Ole KristianSando, Sigrid BotneMeisingset, Tore WergelandChene, GenevieveZhou, WeiTzourio, ChristopheTin, AdrienneLópez, Óscar L.Mary, HaanAiello, Allison E.Børte, SigridBosnes, IngunnVan Duijn, CorneliaCheung, Ching-LungBennett, David A.Chen, ChristopherKamboh, M. IlyasSatizabal, ClaudiaIkram, M. KamranAdams, HieabQiong, YangSchellenberg, Gerard D.Selbæk, GeirHveem, KristianAndreassen, Ole A.Ramírez, AlfredoDufouil, CaroleVan der Flier, WiesjeZwart, John-AnkerDebette, StéphanieFornage, MyriamWinsvold, BendikLambert, Jean-CharlesRuiz, AgustínKehoe, Patrick G.Weinstein, GalitSeshadri, Sudha2025-02-282025-02-282024-09Fongang, B., Sargurupremraj, M., Jian, X., Mishra, A., Damotte, V., de Rojas, I., Skrobot, O., Bis, J. C., Fan, K.-H., Jacobsen, E., Li, G. H.-Y., Yang, J., Alessandra, B., Alessandra, L., Hilal, S., Chong, J. R., Chai, Y. L., Knol, Concas, M. P., et al. (2024). A genome-wide association meta-analysis of all-cause and vascular dementia. Alzheimer’s and Dementia, 20(9), 5973-5995. https://doi.org/10.1002/ALZ.141151552-526010.1002/ALZ.14115http://hdl.handle.net/20.500.14454/2396INTRODUCTION: Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD. METHODS: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. RESULTS: For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonance imaging markers of small vessel disease (SVD; HBEGF). Novel VaD loci were associated with hypertension, diabetes, and neuron maintenance (SPRY2, FOXA2, AJAP1, and PSMA3). DISCUSSION: Our study identified genetic risks underlying ACD, demonstrating overlap with neurodegenerative processes, vascular risk factors, and cerebral SVD. Highlights: We conducted the largest genome-wide association study of all-cause dementia (ACD) and vascular dementia (VaD). Known genetic variants associated with AD were replicated for ACD and VaD. Functional analyses identified novel loci for ACD and VaD. Genetic risks of ACD overlapped with neurodegeneration, vascular risk factors, and cerebral small vessel disease.eng© 2024 The Author(s).All-cause dementiaAlzheimer's diseaseCross-ancestryGenome-wide association study (GWAS)GWAS meta-analysisVascular dementiajournal article2025-02-281552-5279