Rodríguez Lago, IagoAduna, MartaRamírez de la Piscina, PatriciaMerino, OlgaCarrascosa, JuanHiguera, RebecaMaíz, AinaraZapata, EvaCabriada, José LuisBarreiro de Acosta, Manuel2024-11-222024-11-222024-06-14Rodríguez-Lago, I., Aduna, M., Ramírez de la Piscina, P., Merino, O., Carrascosa, J., Higuera, R., Maíz, A., Zapata, E., Cabriada, J. L., & Barreiro-de Acosta, M. (2024). Transmural cross-sectional findings and bowel damage assessment in preclinical Crohn’s disease: a case-control study. International Journal of Colorectal Disease, 39(1). https://doi.org/10.1007/S00384-024-04660-50179-195810.1007/S00384-024-04660-5http://hdl.handle.net/20.500.14454/2096Purpose: Crohn’s disease (CD) is a progressive disorder leading to cumulative bowel damage. The Lémann index is a validated tool that can help in monitoring the progression of the disease and evaluating the effectiveness of different therapies. Our aim was to describe the main radiological findings in incidentally diagnosed CD and to evaluate bowel damage in this subgroup compared to patients diagnosed at later stages. Methods: Patients with an incidental diagnosis of CD during the colorectal cancer screening program were compared to controls with a CD cohort diagnosed after symptomatic onset and matched 1:1 by disease extent. All cross-sectional examinations were centrally read, performing a descriptive analysis of the main findings and calculation of Lémann index. Results: Thirty-eight patients were included: 19 with preclinical CD (median age 55 years (IQR, 54–62), 53% male, 74% non-smokers; 74% B1 and 26% B2) and 19 matched-controls with symptomatic CD. In those with preclinical CD, the most frequent transmural findings on MRE were contrast enhancement (79%), wall thickening (79%), followed by lymphadenopathy (68%), edema (42%), and increased vascularity (42%). Among those with strictures, controls showed a higher rate of preestenotic dilation (100% vs. 0%, p = 0.01). Bowel damage assessment revealed no statistically significant differences in the Lémann index between preclinical CD and controls (p = 0.95). A statistically significant higher score in the colonic/rectum score was observed (p = 0.014). Conclusion: Patients with preclinical CD demonstrate similar radiological findings and degree of bowel damage as new-onset symptomatic CD.eng© The Author(s) 2024Bowel damageCrohn’s diseaseDiagnosisEarlyPreclinicaljournal article2024-11-221432-1262