Delgado-Ortiz, LauraArbillaga Etxarri, AneRodríguez-Chiaradia, Diego A.Gimeno-Santos, ElenaBarberan-Garcia, AnaelBalcells, EvaRodríguez-Roisin, RobertGarcia-Aymerich, Judith2024-11-112024-11-112022-05Delgado-Ortiz, L., Arbillaga-Etxarri, A., Rodríguez-Chiaradía, D. A., Gimeno-Santos, E., Barberan-Garcia, A., Balcells, E., Rodríguez-Roisin, R., & Garcia-Aymerich, J. (2022). Physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease: A cross-sectional analysis. Annals of Physical and Rehabilitation Medicine, 65(3). https://doi.org/10.1016/J.REHAB.2021.1015011877-066510.1016/J.REHAB.2021.101501http://hdl.handle.net/20.500.14454/1736Background: The cardiac autonomic function in patients with chronic obstructive pulmonary disease (COPD) has been poorly studied. Objectives: We aimed to 1) describe the cardiac autonomic function assessed by heart rate recovery (HRR) and chronotropic response (CR) during a 6-min walk test (6MWT) and afterward and 2) estimate the association of physical activity with HRR and CR in COPD patients. Methods: This cross-sectional analysis included 320 patients with mild to very severe COPD. Physical activity (steps, time in any/moderate-to-vigorous/vigorous physical activity, intensity and sedentary time) was measured during 1 week by accelerometer. CR and HRR were measured during a 6MWT and 5 min after, respectively, and their association with physical activity parameters was estimated by multivariable linear regression models. Results: Patients were 82% male and had a mean (SD) age 68 (8) years, post-bronchodilator FEV1 57 (18) % predicted, and walked a mean of 7716 (4139) steps/day. HRR was slow until 5 min after the 6MWT; the mean (SD) HRR was 15 (10), 22 (11), 25 (12), 25 (12) and 27 (12) bpm after 1, 2, 3, 4 and 5 min, respectively. The mean (SD) CR was 35% (16). After adjusting for relevant confounders, time in vigorous physical activity was significantly associated with a fast decrease in HRR (p = 0.044) and an increase in CR (p = 0.021). We found no independent association for other physical activity parameters. Conclusion: A cardiac autonomic dysfunction is present in patients with mild to very severe COPD and is inversely related to the practice of vigorous physical activity. Trial registration ClinicalTrials.gov NCT01897298.eng© 2021 Elsevier Masson SASAutonomic nervous systemChronic obstructiveExerciseHeart ratePulmonary diseasejournal article2024-11-11