Brain white matter correlates of creativity in schizophrenia: a diffusion tensor imaging study

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dc.contributor.authorSampedro, Agurne
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorCabrera Zubizarreta, Alberto
dc.contributor.authorSánchez Gómez, Pedro Manuel
dc.contributor.authorGómez Gastiasoro, Ainara
dc.contributor.authorIriarte Yoller, Nagore
dc.contributor.authorPavón, Cristóbal
dc.contributor.authorOjeda del Pozo, Natalia
dc.date.accessioned2025-06-10T10:45:15Z
dc.date.available2025-06-10T10:45:15Z
dc.date.issued2020-06-23
dc.date.updated2025-06-10T10:45:15Z
dc.description.abstractThe relationship between creativity and psychopathology has been a controversial research topic for decades. Specifically, it has been shown that people with schizophrenia have an impairment in creative performance. However, little is known about the brain correlates underlying this impairment. Therefore, the aim of this study was to analyze whole brain white matter (WM) correlates of several creativity dimensions in people with schizophrenia. Fifty-five patients with schizophrenia underwent diffusion-weighted imaging on a 3T magnetic resonance imaging machine as well as a clinical and a creativity assessment, including verbal and figural creativity measures. Tract-based spatial statistic, implemented in FMRIB Software Library (FSL), was used to assess whole brain WM correlates with different creativity dimensions, controlling for sex, age, premorbid IQ, and medication. Mean fractional anisotropy (FA) in frontal, temporal, subcortical, brain stem, and interhemispheric regions correlated positively with figural originality. The most significant clusters included the right corticospinal tract (cerebral peduncle part) and the right body of the corpus callosum. Verbal creativity did not show any significant correlation. As a whole, these findings suggest that widespread WM integrity is involved in creative performance of patients with schizophrenia. Many of these areas have also been related to creativity in healthy people. In addition, some of these regions have shown to be particularly impaired in schizophrenia, suggesting that these WM alterations could be underlying the worse creative performance found in this pathology.en
dc.description.sponsorshipThis study has been supported by the Spanish Ministry of Economy and Competitiveness (PI16/01022) and the Department of Education and Science of the Basque Government (Team A) (IT946-16). AS was supported by a fellowship from the Fundación Tatiana Pérez de Guzmán el Bueno. AG-G was supported by a fellowship from the Education, Language, Politics and Culture Department of the Basque Government (PRE_2015_1_0444)en
dc.identifier.citationSampedro, A., Peña, J., Ibarretxe-Bilbao, N., Cabrera-Zubizarreta, A., Sánchez, P., Gómez-Gastiasoro, A., Iriarte-Yoller, N., Pavón, C., & Ojeda, N. (2020). Brain white matter correlates of creativity in schizophrenia: a diffusion tensor imaging study. Frontiers in Neuroscience, 14. https://doi.org/10.3389/FNINS.2020.00572
dc.identifier.doi10.3389/FNINS.2020.00572
dc.identifier.eissn1662-453X
dc.identifier.issn1662-4548
dc.identifier.urihttp://hdl.handle.net/20.500.14454/2993
dc.language.isoeng
dc.publisherFrontiers Media S.A.
dc.rights© 2020 Sampedro, Peña, Ibarretxe-Bilbao, Cabrera-Zubizarreta, Sánchez, Gómez-Gastiasoro, Iriarte-Yoller, Pavón and Ojeda
dc.subject.otherCreativity
dc.subject.otherSchizophrenia
dc.subject.otherWhite matter
dc.subject.otherDivergent thinking
dc.subject.otherPsychosis
dc.subject.otherFractional anisotropy
dc.titleBrain white matter correlates of creativity in schizophrenia: a diffusion tensor imaging studyen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.titleFrontiers in Neuroscience
oaire.citation.volume14
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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