Topiramato: neurofarmacología y versatilidad clínica
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2022-06-20
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El topiramato, clasificado como un monosacárido sustituido por sulfamato, es un fármaco en cuya ficha técnica consta la indicación en epilepsia y migraña, pero actualmente también se utiliza en otras cefaleas como la cefalea en racimos, SUNCT (Shortlasting Unilateral Neuralgiform headache attacks with Conjunctival injection and Tearing)-SUNA (Short-lasting Unilateral Neuralgiform headache attacks with cranial Autonomic symptoms), emicránea paroxística, neuralgia del nervio trigémino y cefalea secundaria a hipertensión intracraneal idiopática; dolor neuropático; trastornos del movimiento como temblor, tics y síndrome de Tourette; parasomnias; trastornos adictivos por consumo de alcohol u otras sustancias; trastornos alimentarios como bulimia y obesidad, entre otros; trastorno de estrés postraumático, trastorno bipolar y trastorno obsesivo-compulsivo. Este trabajo tiene como objetivo revisar el conocimiento y los usos clínicos de topiramato, tanto los incluidos en su ficha técnica como otros, y el nivel de evidencia de estos.
Topiramate, which is classified as a sulphamate-substituted monosaccharide, is a drug whose data sheet shows its indication in epilepsy and migraine, although it is also used in other headaches such as cluster headache, SUNCT-SUNA, paroxysmal hemicrania, trigeminal nerve neuralgia, and headache secondary to idiopathic intracranial hypertension; neuropathic pain; movement disorders such as tremor, tics and Tourette’s syndrome; parasomnias; addictive disorders due to alcohol consumption or other substances; eating disorders such as bulimia or obesity, among others; post-traumatic stress disorder, bipolar disorder and obsessive-compulsive disorder. The aim of this paper is to review the knowledge and clinical uses of topiramate, both those included in its technical data sheet and those that are not, and the level of evidence for them.
Topiramate, which is classified as a sulphamate-substituted monosaccharide, is a drug whose data sheet shows its indication in epilepsy and migraine, although it is also used in other headaches such as cluster headache, SUNCT-SUNA, paroxysmal hemicrania, trigeminal nerve neuralgia, and headache secondary to idiopathic intracranial hypertension; neuropathic pain; movement disorders such as tremor, tics and Tourette’s syndrome; parasomnias; addictive disorders due to alcohol consumption or other substances; eating disorders such as bulimia or obesity, among others; post-traumatic stress disorder, bipolar disorder and obsessive-compulsive disorder. The aim of this paper is to review the knowledge and clinical uses of topiramate, both those included in its technical data sheet and those that are not, and the level of evidence for them.
Palabras clave
Epilepsia
Cefalea
Dolor
Trastornos del movimiento
Prescripción fuera de ficha técnica
Topiramato
Epilepsy
Headache
Pain
Movement disorders
Off-label prescribing
Topiramate
Cefalea
Dolor
Trastornos del movimiento
Prescripción fuera de ficha técnica
Topiramato
Epilepsy
Headache
Pain
Movement disorders
Off-label prescribing
Topiramate
Descripción
Materias
Cita
Mínguez-Olaondo, A. (2022). Topiramato: neurofarmacología y versatilidad clínica. Kranion, 17, 20-25. https://doi.org/10.24875/KRANION.M22000035